provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Ledipasvir / Sofosbuvir Coupon - Ledipasvir / Sofosbuvir 90mg/400mg tablet

ledipasvir / sofosbuvir

Generic Harvoni
Used for Hepatitis C
Used for Hepatitis C

Harvoni (ledipasvir / sofosbuvir) is a combination medication containing two antiviral medications, ledipasvir and sofosbuvir (Sovaldi). It is a first-choice treatment option for hepatitis C for certain types of people.

Reviewed by:
reviewer
Hope Chang, PharmD, AAHIVP
reviewer
Michelle Nguyen, PharmD
Last reviewed on May 3, 2021
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesLatest newsImagesPricesMedicare
basics-icon

What is Harvoni (ledipasvir / sofosbuvir)?

What is Harvoni (ledipasvir / sofosbuvir) used for?

  • Hepatitis C infection genotype 1, 4, 5, and 6

How Harvoni (ledipasvir / sofosbuvir) works

Harvoni (ledipasvir / sofosbuvir) contains 2 antiviral medications that work together to stop the hepatitis C virus from making copies of itself in the body.

Drug Facts

Common BrandsHarvoni
Drug ClassAntiviral Combo
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$15156.87(save 33.43%)
GoodRx discount
$10090.51
See prices
basics-icon

What are the side effects of Harvoni (ledipasvir / sofosbuvir)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (14%)
  • Fatigue or tiredness (13%)
  • Nausea (7%)

Other Side Effects

  • Diarrhea
  • Difficulty sleeping (insomnia)

Source: FDA

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Slow heartbeat—dizziness, feeling faint or lightheaded, confusion, trouble breathing, unusual weakness or fatigue

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Harvoni (ledipasvir / sofosbuvir)

thumbs-up

Pros

Taking the medication for 6 months or less is very effective against hepatitis C

Few side effects; most common are stomachache, tiredness, and headache

Can be used in children age 3 years or older

Available as a generic, which can be more affordable

Available as an oral pellet for people who can't swallow the tablet or need their dose lowered

thumbs-down

Cons

Heartburn and stomach acid-lowering medications can lower the amount of Harvoni (ledipasvir / sofosbuvir) in your body

Not a good option for people taking amiodarone, because the combination can cause slow heart rate

Doesn't treat all the types of hepatitis C like other antiviral combos, such as Epclusa or Mavyret

Interacts with some HIV antiretroviral medications

Some people who have hepatitis B and C have had their hepatitis B come back after taking hepatitis C treatment

pharmacist-tips

Pharmacist tips for Harvoni (ledipasvir / sofosbuvir)

pharmacist

  • Make sure you take your prescribed dose every day at the same time with or without food. Make sure you continue to take the medication until your provider instructs you to stop.

    • If you happen to be hospitalized during your course of heptitis C treatment, make sure you bring your antiviral medications with you to the hospital. Most hospitals do not have hepatitis C medications in stock because they are expensive. They have procedures in place to administer your home medications so that your treatment will not be interupted.

      • Tell your hepatitis C provider about all the medications you are taking. Harvoni (ledipasvir / sofosbuvir) interacts with a lot of common medications like famotidine (Pepcid), omeprazole (Prilosec), cholesterol-lowering statins, and HIV antiretrovirals. The interacting medications may need their dose lowered or scheduled around your Harvoni (ledipasvir / sofosbuvir) dose.

        • Headaches are a common side effect. You can use over-the-counter acetaminophen (Tylenol) to treat them, but be sure to take less than 2000 mg a day to prevent liver damage. NSAIDs like ibuprofen (Advil) and naproxen (Aleve) are not recommended in people with severe liver problems.

          • Do not chew the oral pellets. They can either be taken directly from the packet or sprinkled on non-acidic soft food. Non-acidic soft food include: pudding, chocolate syrup, mashed potatoes, and ice cream.

            faqs

            Frequently asked questions about Harvoni (ledipasvir / sofosbuvir)

            Does Harvoni (ledipasvir / sofosbuvir) cure hepatitis C?
            Yes, a successful treatment with antivirals is considered a cure for heptitis C. In clinical trials, Harvoni (ledipasvir / sofosbuvir) cured 94% to 100% cases of hepatitis C genotype 1.
            Can hep C come back after taking Harvoni (ledipasvir / sofosbuvir)?
            It's not likely that heptitis C will come back after achieving "SVR," which is considered a cure. However, treatment of hepatitis C doesn't make you immune to the virus, so it's possible to become reinfected. After treatment it's important to continue to protect yourself from hepatitis C and not receive unclean tattoos or share things like razors and needles.
            Can you drink alcohol while taking Harvoni (ledipasvir / sofosbuvir)?
            Avoid alcohol while taking Harvoni (ledipasvir / sofosbuvir). It's not known if alcohol interacts with the medication, but alcohol and hepatitis C can both damage the liver.
            Who makes Harvoni (ledipasvir / sofosbuvir)?
            In the U.S., Gilead makes branded Harvoni (ledipasvir / sofosbuvir). Asegua Therapeutics makes the authorized generic of Harvoni.
            Which is better, Epclusa or Harvoni (ledipasvir / sofosbuvir)?
            Both antiviral medications are very good at curing hepatitis C. Epclusa works for all genotypes of hepatitis C, while Harvoni (ledipasvir / sofosbuvir) works for 4 out of 6 types. Harvoni (ledipasvir / sofosbuvir) can cure hepatitic C in just 8 weeks for certain types of people; the shortest course of Epclusa is 12 weeks.
            GoodRxEducationalIcon

            How to save using GoodRx

            Compare Prices
            1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
            Select your free coupon
            2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
            Show coupon to your pharmacist
            3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
            Get free couponLearn more
            warings-icon

            What are the risks and warnings for Harvoni (ledipasvir / sofosbuvir)?

            Harvoni (ledipasvir / sofosbuvir) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            HEPATITIS B REACTIVATION

            • Risk factors: History of hepatitis B infection

              Some people who have both hepatitis B and C have had their hepatitis B reactivate or flare up after starting treatment for hepatitic C. This can cause liver problems if not caught and treated. You should be tested for hepatitis B before you start Harvoni (ledipasvir / sofosbuvir). Tell your provider if you've ever had hepatitis B or been treated for it in the past.

              risk-warning

              SLOW HEART RATE

              • Risk factors: Amiodarone | Beta blockers | Heart disease | Liver disease

                There have been cases of slow heartbeat and fatal heart problems when people take amiodarone (Pacerone) and Harvoni (ledipasvir / sofosbuvir) together. It usually happens right after Harvoni (ledipasvir / sofosbuvir) is started, but can also happen weeks after the combination is taken. It's more likely to happen in people also taking beta blockers or with severe liver problems. Tell your provider if you are taking or have recently taken amiodarone. They may choose a different hepatitis C medication for you, or closely monitor your heartbeat. Go to the emergency room right away if you take these medications together and feel faint, dizzy, weak, or have trouble breathing.

                risk-warning

                RIBAVIRIN RISKS

                • Risk factors: Taking ribavirin with Harvoni (ledipasvir / sofosbuvir)

                  People with certain types of liver problems may need to take an antiviral medication called ribavirin in addition to Harvoni (ledipasvir / sofosbuvir). Ribavirin can have a lot of side effects and should not be taken during pregnancy. Make sure to review this medication with your provider and pharmacist before starting your hepatitis C treatment.

                  dosage

                  Harvoni (ledipasvir / sofosbuvir) dosage forms

                  Typical dosing for Harvoni (ledipasvir / sofosbuvir)

                  Adults: 1 tablet once a day with or without food. The standard tablet contains 90 mg of ledipasvir and 400 mg of sofosbuvir.

                  Children: dose is based on the child's weight

                  drug-cost

                  How much does Harvoni (ledipasvir / sofosbuvir) cost?

                  To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                  Harvoni (brand)
                  GoodRx lowest price

                  $31381.01

                  (save 12.18%)
                  Harvoni (ledipasvir / sofosbuvir) (generic)
                  GoodRx lowest price

                  $10090.51

                  (save 33.43%)
                  View prices & coupons
                  alternatives

                  What are alternatives to Harvoni (ledipasvir / sofosbuvir)?

                  There are a number of medications that your doctor can prescribe in place of Harvoni (ledipasvir / sofosbuvir). Compare a few possible alternatives below.
                  Harvoni (ledipasvir / sofosbuvir)
                  Used for:

                  • Hepatitis C infection genotype 1, 4, 5, and 6

                  $10090.51 Lowest GoodRx priceView Prices
                  Epclusa (sofosbuvir / velpatasvir)
                  Used for:

                  • Chronic hepatitis C infection

                  $6730.50 Lowest GoodRx priceView Prices
                  Zepatier (elbasvir / grazoprevir)
                  Used for:

                  • Hepatitis C infection genotype 1 and 4

                  $7257.89 Lowest GoodRx priceView Prices
                  latest news

                  What is the latest news about Harvoni (ledipasvir / sofosbuvir)?

                  Harvoni and Mavyret are both antiviral medications that treat hepatitis C. Learn about these two medications and how they differ.

                  Harvoni vs. Mavyret for Hepatitis C: 6 Things to Be Aware Of

                  Harvoni and Mavyret are both antiviral medications that treat hepatitis C. Learn about these two medications and how they differ.
                  Harvoni and Epclusa are both antiviral medications that treat hepatitis C. Learn how they compare, including dosages, side effects, and more.

                  Harvoni vs. Epclusa for Hepatitis C: 5 Similarities and Differences to Consider

                  Harvoni and Epclusa are both antiviral medications that treat hepatitis C. Learn how they compare, including dosages, side effects, and more.
                  Hepatitis C treatment can cost $22,000 to $95,000 or more if you don’t have insurance. You could pay far less with insurance. Learn about costs and how to save.

                  How Much Does Hepatitis C Treatment Cost With and Without Insurance?

                  Hepatitis C treatment can cost $22,000 to $95,000 or more if you don’t have insurance. You could pay far less with insurance. Learn about costs and how to save.
                  Read on to learn the common and rare side effects of taking Harvoni for hepatitis C and how to manage them.

                  9 Harvoni Side Effects You Should Know About

                  Read on to learn the common and rare side effects of taking Harvoni for hepatitis C and how to manage them.
                  Medicare typically covers Hepatitis C treatments under Part D. Learn about the cost of screenings, medications like direct-acting antivirals (DAAs), and more.

                  Does Medicare Cover Hepatitis C Treatment?

                  Medicare typically covers Hepatitis C treatments under Part D. Learn about the cost of screenings, medications like direct-acting antivirals (DAAs), and more.
                  Hepatitis C can be treated with antiviral medications. This includes direct-acting antivirals, such as Mavyret and Epclusa, as well as ribavirin and interferon.

                  From Interferon to Vosevi: 8 Hepatitis C Medications to Know About

                  Hepatitis C can be treated with antiviral medications. This includes direct-acting antivirals, such as Mavyret and Epclusa, as well as ribavirin and interferon.
                  Thanks to new medications, like Harvoni and Epclusa, hep C is curable for most people. Learn how these new hep C treatments work and how much they cost here.

                  Is Hepatitis C Curable? Treatments and Outlook

                  Thanks to new medications, like Harvoni and Epclusa, hep C is curable for most people. Learn how these new hep C treatments work and how much they cost here.
                  Hepatitis C is inflammation of the liver that the hepatitis C virus causes. Learn the symptoms of acute and chronic hepatitis C infection – with GoodRx.

                  Symptoms of Acute and Chronic Hepatitis C

                  Hepatitis C is inflammation of the liver that the hepatitis C virus causes. Learn the symptoms of acute and chronic hepatitis C infection – with GoodRx.
                  GoodRx has completed the largest library of brand-drug savings programs on the internet, featuring over 800 manufacturer discount programs and 1,300

                  GoodRx Builds the Largest Database for Copay Savings Programs and Patient Assistance Programs for Over 1,600 Drugs

                  GoodRx has completed the largest library of brand-drug savings programs on the internet, featuring over 800 manufacturer discount programs and 1,300
                  images

                  Harvoni (ledipasvir / sofosbuvir) images

                  Orange Diamond Ase And 9875 - Ledipasvir and Sofosbuvir 90mg-400mg Tablet
                  This medicine is Orange, Diamond Tablet Imprinted With "9875" And "Ase".Orange Diamond Ase And 9875 - Ledipasvir and Sofosbuvir 90mg-400mg Tablet

                  Get savings updates for Harvoni (ledipasvir / sofosbuvir)

                  Receive price alerts, news, and other messages from GoodRx about Harvoni (ledipasvir / sofosbuvir) and other healthcare topics and relevant savings offers.

                  By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                  Compare other Hepatitis C drugs

                  Harvoni vs CopegusHarvoni vs EpclusaHarvoni vs MavyretHarvoni vs OlysioHarvoni vs Zepatier
                  View More

                  Browse medications

                  View All

                  Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.