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Compare Viekira Pak vs. Olysio

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Viekira Pak (dasabuvir, ombitasvir, paritaprevir, and ritonavir) and Olysio (simeprevir) are both antiviral medications used to treat hepatitis C. However, they differ in several ways. Viekira Pak is a combination medication that includes three antiviral agents and a booster, ritonavir, and is specifically FDA-approved for hepatitis C genotype 1. It is taken orally with a specific dosing schedule of four tablets per day and is still available by prescription. In contrast, Olysio (simeprevir) was used in combination with peginterferon and ribavirin, but it has been discontinued and is no longer available in the U.S. Viekira Pak can cause side effects like fatigue, nausea, and itching, and it has significant drug interactions, especially with medications containing estrogen. Olysio required additional medications that had many side effects, which contributed to its discontinuation. While Viekira Pak offers a complete regimen for hepatitis C, Olysio was not a standalone treatment.

  • Viekira pak
    Olysio (simeprevir)
  • Viekira pak
    Olysio (simeprevir)

  • Summary of Viekira Pak vs. Olysio

    Summary for Antiviral Combo
    Prescription only

    Viekira Pak is a combination medication containing 3 antiviral medications, ombitasvir, paritaprevir, and dasabuvir and a booster medication, ritonavir. It's a treatment option for hepatitis C type 1.

    Summary for Antiviral

    Olysio (simeprevir) is an oral medication that was used with other medications to treat hepatitis C. It is no longer available and has been replaced by newer antiviral medications.

  • Indications of Viekira Pak vs. Olysio

    Indications for
    •Hepatitis C infection genotype 1
    Indications for

  • Pros and Cons of Viekira Pak vs. Olysio

    Pros and Const for Antiviral Combo
    Pros
    •Works well to cure hepatitis C
    •Comes in easy to follow dose packaging
    •Not too many side effects; most common include nausea, tiredness, itching, and rash
    •Treatment length can be as short as 12 weeks
    •Can be used in people who have received a liver transplant
    Cons
    •Only works for genotype 1
    •Some people with severe liver problems may need to take another antiviral medication called ribavirin
    •Requires 4 tablets a day, where other regimens can be as few as 1 tablet
    •Contains a booster medication called ritonavir (Norvir), which interacts with a lot of medications
    •Can't be taken with birth control that contains ethynyl estradiol
    Pros and Const for Antiviral
    Pros
    Cons

  • Common Side Effects of Viekira Pak vs. Olysio

    Common Side Effects for
    •Fatigue (34%)
    •Nausea (22%)
    •Itching (18%)
    •Rash (16%)
    •Insomnia (4%)
    •Weakness (14%)
    Common Side Effects for

  • Warnings of Viekira Pak vs. Olysio

    Common Side Effects for
    •HEPATITIS B REACTIVATION
    •SERIOUS LIVER PROBLEMS
    •HIGH LIVER BLOOD TESTS
    •RIBAVIRIN RISKS
    •DRUG INTERACTIONS
    Common Side Effects for

  • Prices with our coupons for Viekira Pak vs. Olysio

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    Learn more about Olysio

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