Key takeaways
Harvoni (ledipasvir/sofosbuvir) and Zepatier (elbasvir/grazoprevir) are both antiviral combination medications used to treat hepatitis C, but they have some key differences. Harvoni is effective against hepatitis C genotypes 1, 4, 5, and 6, while Zepatier is only used for genotypes 1 and 4. Harvoni can be used in children as young as 3 years old and is available in a generic form, which can make it more affordable. On the other hand, Zepatier is a good option for people with kidney problems, including those on hemodialysis, and does not interact with stomach acid-lowering medications. However, Zepatier requires resistance testing for people with genotype 1 before starting therapy and cannot be used in individuals with cirrhosis or moderate to severe liver problems. Both medications have similar common side effects, such as headache, fatigue, and nausea. Additionally, Harvoni interacts with more medications, including some HIV antiretrovirals and heart medications like amiodarone, which can cause slow heart rate.
