Key takeaways
Harvoni (ledipasvir/sofosbuvir) and Epclusa (sofosbuvir/velpatasvir) are both antiviral medications used to treat hepatitis C. Harvoni is effective for hepatitis C genotypes 1, 4, 5, and 6, while Epclusa works for all six genotypes. Harvoni can sometimes cure hepatitis C in just 8 weeks for certain people, whereas the shortest course for Epclusa is 12 weeks. Both are available in generic forms. Both medications can interact with other drugs, especially those for heartburn and HIV, and neither should be taken with amiodarone due to the risk of slow heart rate. Common side effects for both include headache and fatigue, but Harvoni can also cause nausea, while Epclusa may cause skin rash and weakness.
