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Sofosbuvir / Velpatasvir Coupon - Sofosbuvir / Velpatasvir 28 tablets of 400mg/100mg dose pack

sofosbuvir / velpatasvir

Generic Epclusa
Used for Hepatitis C
Used for Hepatitis C

Epclusa (sofosbuvir / velpatasvir) is a combination medication containing two antiviral medications, sofosbuvir and velpatasvir, that's used to treat chronic hepatitis C in adults and children.

Reviewed by:
reviewer
Hope Chang, PharmD, AAHIVP
reviewer
ThienLy Neal, PharmD
Last reviewed on May 3, 2021
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesLatest newsImagesPricesMedicare
basics-icon

What is Epclusa (sofosbuvir / velpatasvir)?

What is Epclusa (sofosbuvir / velpatasvir) used for?

  • Chronic hepatitis C infection

How Epclusa (sofosbuvir / velpatasvir) works

Epclusa (sofosbuvir / velpatasvir) contains 2 antiviral medications that work together to stop the hepatitis C virus from making copies of itself in the body.

Are you looking for information on Vosevi (sofosbuvir / velpatasvir / voxilaprevir) instead?

Drug Facts

Common BrandsEpclusa
Drug ClassAntiviral
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Epclusa (sofosbuvir / velpatasvir)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache
  • Fatigue

Other Side Effects

  • Skin rash
  • Nausea
  • Weakness
  • Difficulty sleeping
  • Diarrhea

Source: FDA

More on Epclusa (sofosbuvir / velpatasvir) side effects

Health: Epclusa: senior woman taking medication bright room-1317543683

What Are the Side Effects of Epclusa?

Written by ThienLy Neal, PharmD

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Epclusa (sofosbuvir / velpatasvir)

thumbs-up

Pros

Treats all 6 types of hepatitis C

Most people only have to take one pill once a day for 12 weeks

Can be taken with or without food

Most common side effects are usually mild, such as fatigue and headache

thumbs-down

Cons

Interacts with many medications including those used for heartburn

Not a good option for people taking amiodarone (Pacerone) because the combination can cause slow heart rate

Some people with severe liver problems who have chronic hepatitis C may need to take it with another antiviral medication called ribavirin

Can reactivate the hepatitis B virus if you have a history of hepatitis B infection

pharmacist-tips

Pharmacist tips for Epclusa (sofosbuvir / velpatasvir)

pharmacist

  • Let your provider know if you have ever been treated for hepatitis B or C in the past. Your provider might change your medication treatment and lab monitoring based on your treatment history.

    • Make sure you take your prescribed dose every day at the same time with or without food. Continue to take the medication until your provider instructs you to stop.

      • If you happen to be hospitalized during your course of hepatitis C treatment, make sure you bring your antiviral medications with you to the hospital. Most hospitals do not have hepatitis C medications in stock because they are expensive. They have procedures in place to administer your home medications so that your treatment will not be interrupted.

        • Tell your hepatitis C provider about all the medications you are taking. Epclusa (sofosbuvir / velpatasvir) interacts with a lot of common medications like famotidine (Pepcid AC), omeprazole (Prilosec), and cholesterol-lowering statins. The interacting medications might need their dose lowered or scheduled around your Epclusa (sofosbuvir / velpatasvir) dose.

          faqs

          Frequently asked questions about Epclusa (sofosbuvir / velpatasvir)

          Does Epclusa (sofosbuvir / velpatasvir) cure hepatitis C?
          Yes, a successful treatment with Epclusa (sofosbuvir / velpatasvir) is considered a cure for hepatitis C when there are no detectable hepatitis C viruses found in the body. In clinical trials, Epclusa (sofosbuvir / velpatasvir) had very successful cure rates of up to 100% for hepatitis C.
          Can hepatitis C come back after taking Epclusa (sofosbuvir / velpatasvir)?
          It's not likely that hepatitis C will come back after successful treatment with Epclusa (sofosbuvir / velpatasvir). However, treatment of hepatitis C doesn't make you immune to the virus, so it's possible to become reinfected. After treatment, it's important to continue to protect yourself from hepatitis C and not share things like razors and needles.
          Can you drink alcohol while taking Epclusa (sofosbuvir / velpatasvir)?
          Avoid alcohol while taking Epclusa (sofosbuvir / velpatasvir). It's not known if alcohol interacts with the medication, but alcohol and hepatitis C can both damage the liver.
          Which is better, Harvoni or Epclusa (sofosbuvir / velpatasvir)?
          Both antiviral medications are very good at curing hepatitis C. The biggest difference is that Epclusa (sofosbuvir / velpatasvir) works for all types of hepatitis C, while Harvoni works for 4 out of 6 types.
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          What are the risks and warnings for Epclusa (sofosbuvir / velpatasvir)?

          Epclusa (sofosbuvir / velpatasvir) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Hepatitis B reactivation

          • Risk factors: History of hepatitis B infection

            Some people who have both hepatitis B and C have had their hepatitis B reactivated or flare up after starting treatment for hepatitis C. This can cause liver problems and even death if not caught early and treated. You should get tested for hepatitis B before you start Epclusa (sofosbuvir / velpatasvir). Tell your provider if you've ever had hepatitis B or been treated for it in the past.

            risk-warning

            Slow heart rate

            • Risk factors: Also taking amiodarone | Also taking beta blockers | History of heart disease | History of advanced liver disease

              There have been cases of slow heart rate and fatal heart problems when people take amiodarone and Epclusa (sofosbuvir / velpatasvir) together. It usually happens right after Epclusa (sofosbuvir / velpatasvir) is started, but can also happen weeks after the combination is taken. It's also more likely to happen in people taking beta blockers or those with advanced liver disease or underlying heart disease. Tell your provider if you are taking or have recently taken amiodarone. They may choose a different hepatitis C medication for you, or closely monitor your heart rate. Go to the emergency room right away if you take these medications together and feel faint, dizzy, weak, or have trouble breathing.

              risk-warning

              Ribavirin risks

              • Risk factors: Taking ribavirin with Epclusa (sofosbuvir / velpatasvir)

                People with certain types of liver problems may need to take an antiviral medication called ribavirin in addition to Epclusa (sofosbuvir / velpatasvir). Ribavirin can have a lot of side effects, so make sure to review this medication with your provider and pharmacist before starting your hepatitis C treatment.

                risk-warning

                Interactions with other medications

                Epclusa (sofosbuvir / velpatasvir) interacts with many medications and a few herbal supplements. Medications such as rifampin (Rifadin), carbamazepine (Tegretol), and herbal supplements like St. John's wort can lower the amount of Epclusa (sofosbuvir / velpatasvir) in your body which can make the medication not work as well. It's important to let your provider and pharmacist know all the medications you're currently taking, including vitamins, herbal supplements, and over-the-counter (OTC) medications.

                dosage

                Epclusa (sofosbuvir / velpatasvir) dosage forms

                Typical dosing for Epclusa (sofosbuvir / velpatasvir)

                Adults: The recommended dose is 1 tablet (400 mg of sofosbuvir and 100 mg of velpatasvir) by mouth once a day.

                Children age 3 or older: The dose is based on your child's weight

                • Less than 17 kg: one 150 mg/37.5 mg (sofosbuvir/velpatasvir) packet of pellets by mouth once a day.

                • 17 to 30 kg: one 200 mg/50 mg (sofosbuvir/velpatasvir) packet of pellets by mouth once a day.

                • 30 kg and more: two 200 mg/50 mg (sofosbuvir/velpatasvir) packet of pellets by mouth once a day.

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                How much does Epclusa (sofosbuvir / velpatasvir) cost?

                To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                Epclusa (brand)
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                alternatives

                What are alternatives to Epclusa (sofosbuvir / velpatasvir)?

                There are a number of medications that your doctor can prescribe in place of Epclusa (sofosbuvir / velpatasvir). Compare a few possible alternatives below.
                Epclusa (sofosbuvir / velpatasvir)
                Used for:

                • Chronic hepatitis C infection

                $6730.50 Lowest GoodRx priceView Prices
                Harvoni (ledipasvir / sofosbuvir)
                Used for:

                • Hepatitis C infection genotype 1, 4, 5, and 6

                $10090.51 Lowest GoodRx priceView Prices
                Zepatier (elbasvir / grazoprevir)
                Used for:

                • Hepatitis C infection genotype 1 and 4

                $7256.88 Lowest GoodRx priceView Prices
                latest news

                What is the latest news about Epclusa (sofosbuvir / velpatasvir)?

                Harvoni and Epclusa are both antiviral medications that treat hepatitis C. Learn how they compare, including dosages, side effects, and more.

                Harvoni vs. Epclusa for Hepatitis C: 5 Similarities and Differences to Consider

                Harvoni and Epclusa are both antiviral medications that treat hepatitis C. Learn how they compare, including dosages, side effects, and more.
                Hepatitis C treatment can cost $22,000 to $95,000 or more if you don’t have insurance. You could pay far less with insurance. Learn about costs and how to save.

                How Much Does Hepatitis C Treatment Cost With and Without Insurance?

                Hepatitis C treatment can cost $22,000 to $95,000 or more if you don’t have insurance. You could pay far less with insurance. Learn about costs and how to save.
                Medicare typically covers Hepatitis C treatments under Part D. Learn about the cost of screenings, medications like direct-acting antivirals (DAAs), and more.

                Does Medicare Cover Hepatitis C Treatment?

                Medicare typically covers Hepatitis C treatments under Part D. Learn about the cost of screenings, medications like direct-acting antivirals (DAAs), and more.
                Hepatitis C can be treated with antiviral medications. This includes direct-acting antivirals, such as Mavyret and Epclusa, as well as ribavirin and interferon.

                From Interferon to Vosevi: 8 Hepatitis C Medications to Know About

                Hepatitis C can be treated with antiviral medications. This includes direct-acting antivirals, such as Mavyret and Epclusa, as well as ribavirin and interferon.
                Thanks to new medications, like Harvoni and Epclusa, hep C is curable for most people. Learn how these new hep C treatments work and how much they cost here.

                Is Hepatitis C Curable? Treatments and Outlook

                Thanks to new medications, like Harvoni and Epclusa, hep C is curable for most people. Learn how these new hep C treatments work and how much they cost here.
                Hepatitis C is inflammation of the liver that the hepatitis C virus causes. Learn the symptoms of acute and chronic hepatitis C infection – with GoodRx.

                Symptoms of Acute and Chronic Hepatitis C

                Hepatitis C is inflammation of the liver that the hepatitis C virus causes. Learn the symptoms of acute and chronic hepatitis C infection – with GoodRx.
                Epclusa is a medication to treat Hepatitis C in adults. This article examines common and serious side effects, and when to see a healthcare provider about using Epclusa.

                What Are the Side Effects of Epclusa?

                Epclusa is a medication to treat Hepatitis C in adults. This article examines common and serious side effects, and when to see a healthcare provider about using Epclusa.
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