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Compare Harvoni vs. Mavyret

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Harvoni (ledipasvir/sofosbuvir) and Mavyret (glecaprevir/pibrentasvir) are both antiviral medications used to treat hepatitis C, but they have some differences. Harvoni is available in both brand and generic forms, while Mavyret is only available as a brand. Harvoni treats hepatitis C genotypes 1, 4, 5, and 6, whereas Mavyret treats all six genotypes. Harvoni is typically taken once a day for 8 to 12 weeks, while Mavyret is usually taken once a day for 8 to 16 weeks, depending on your treatment history. Mavyret can be taken with antacids and other heartburn medications, unlike Harvoni. Both medications can reactivate hepatitis B in people with a history of the infection, but Mavyret is not recommended for those with severe liver problems. Common side effects for both include headache, tiredness, and nausea.

  • Harvoni (ledipasvir / sofosbuvir)
    Mavyret (glecaprevir / pibrentasvir)
  • Harvoni (ledipasvir / sofosbuvir)
    Mavyret (glecaprevir / pibrentasvir)

  • Summary of Harvoni vs. Mavyret

    Summary for Antiviral Combo
    Prescription only

    Harvoni (ledipasvir / sofosbuvir) is a combination medication containing two antiviral medications, ledipasvir and sofosbuvir (Sovaldi). It is a first-choice treatment option for hepatitis C for certain types of people.

    Summary for Antiviral
    Prescription only

    Mavyret (glecaprevir / pibrentasvir) is a combination medication containing two antivirals, glecaprevir and pibrentasvir. It's a first-choice option that's used to treat many forms of hepatitis C infection. If you've never taken hepatitis C treatment before, you'll need to take Mavyret (glecaprevir / pibrentasvir) for 8 weeks. But if you're already been treated for hepatitis C before you start this medication, your Mavyret (glecaprevir / pibrentasvir) treatment duration might be longer. The most common, short-term side effects include headache, tiredness, and nausea.

  • Indications of Harvoni vs. Mavyret

    Indications for
    •Hepatitis C infection genotype 1, 4, 5, and 6
    Indications for
    •Chronic (long-term) hepatitis C genotype 1, 2, 3, 4, 5, or 6 infection in certain people age 3 years and older
    •Hepatitis C genotype 1 infection in people age 3 years and older who were previously treated with an NS5A inhibitor or an HCV protease inhibitor (not both)

  • Pros and Cons of Harvoni vs. Mavyret

    Pros and Const for Antiviral Combo
    Pros
    •Taking the medication for 6 months or less is very effective against hepatitis C
    •Few side effects; most common are stomachache, tiredness, and headache
    •Can be used in children age 3 years or older
    •Available as a generic, which can be more affordable
    •Available as an oral pellet for people who can't swallow the tablet or need their dose lowered
    Cons
    •Heartburn and stomach acid-lowering medications can lower the amount of Harvoni (ledipasvir / sofosbuvir) in your body
    •Not a good option for people taking amiodarone, because the combination can cause slow heart rate
    •Doesn't treat all the types of hepatitis C like other antiviral combos, such as Epclusa or Mavyret
    •Interacts with some HIV antiretroviral medications
    •Some people who have hepatitis B and C have had their hepatitis B come back after taking hepatitis C treatment
    Pros and Const for Antiviral
    Pros
    •Works against six types of hepatitis C
    •Only need to take once a day
    •Only have to take it for 8 weeks for some people
    •Available as oral pellets for children who have a hard time swallowing tablets
    •Can take with antacids and other heartburn medications, unlike other treatment options
    Cons
    •Brand name only
    •Need to take multiple tablets or use multiple oral pellet packets at one time
    •Can reactivate hepatitis B in people who have a history of hepatitis B infection
    •Not a good option for people who have severe liver problems
    •Can interact with certain medications, including HIV medications, statins, antiseizure medications, and blood thinners

  • Common Side Effects of Harvoni vs. Mavyret

    Common Side Effects for
    •Headache (14%)
    •Fatigue or tiredness (13%)
    •Nausea (7%)
    Common Side Effects for
    •Headache (13%)
    •Fatigue or tiredness (11%)
    •Nausea (8%)

  • Warnings of Harvoni vs. Mavyret

    Common Side Effects for
    •HEPATITIS B REACTIVATION
    •SLOW HEART RATE
    •RIBAVIRIN RISKS
    Common Side Effects for
    •Hepatitis B reactivation
    •Worsening liver health
    •Taking medications that make Mavyret (glecaprevir / pibrentasvir) not work as well

  • Prices with our coupons for Harvoni vs. Mavyret

    Learn more about Harvoni
    Learn more about Mavyret

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