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Compare Zepatier vs. Olysio

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Zepatier (elbasvir/grazoprevir) and Olysio (simeprevir) are both antiviral medications used to treat hepatitis C. However, they differ in several ways. Zepatier is a combination medication containing two antiviral agents, elbasvir and grazoprevir, and is FDA-approved for treating hepatitis C genotypes 1 and 4. It is taken as one tablet once a day and is still available by prescription. In contrast, Olysio (simeprevir) was used in combination with peginterferon and ribavirin, but it has been discontinued and is no longer available in the U.S. Zepatier can be used by people with kidney problems and usually has mild side effects like fatigue and headache. It also doesn't interact with stomach acid medications. On the other hand, Olysio required additional medications that had many side effects, which contributed to its discontinuation. Zepatier can interact with other medications, so it's important to inform your healthcare provider about all the medications you are taking.

  • Zepatier (elbasvir / grazoprevir)
    Olysio (simeprevir)
  • Zepatier (elbasvir / grazoprevir)
    Olysio (simeprevir)

  • Summary of Zepatier vs. Olysio

    Summary for Antiviral Combo
    Prescription only

    Zepatier (elbasvir / grazoprevir) is a combination medication containing two antiviral medications, elbasvir and grazoprevir. It's one of the first choice treatment options for hepatitis C genotypes 1 and 4.

    Summary for Antiviral

    Olysio (simeprevir) is an oral medication that was used with other medications to treat hepatitis C. It is no longer available and has been replaced by newer antiviral medications.

  • Indications of Zepatier vs. Olysio

    Indications for
    •Hepatitis C infection genotype 1 and 4
    Indications for

  • Pros and Cons of Zepatier vs. Olysio

    Pros and Const for Antiviral Combo
    Pros
    •1 tablet once a day is a full regimen for some people and can cure hepatitis C
    •Doesn't interact with stomach acid medications like Epclusa and Harvoni
    •Can be taken by people with kidney problems, even those on hemodialysis
    •Usually has mild side effects
    •Good option for people taking amiodarone, since it doesn't contain sofosbuvir which can cause slow heartbeat
    Cons
    •Doesn't treat all the types of hepatitis C like other antiviral combos such as Epclusa or Mavyret
    •People with hepatitis C type 1 need to have resistance testing before starting therapy
    •Can't be used in people with cirrhosis or moderate to severe liver problems
    •Some people who have hepatitis B and C have had their hepatitis B come back after taking hepatitis C treatment
    •Some people need to take Zepatier (elbasvir / grazoprevir) with an antiviral medication called ribavirin, which can have a lot of side effects
    Pros and Const for Antiviral
    Pros
    Cons

  • Common Side Effects of Zepatier vs. Olysio

    Common Side Effects for
    •Fatigue (11%)
    •Headache (10%)
    Common Side Effects for

  • Warnings of Zepatier vs. Olysio

    Common Side Effects for
    •HEPATITIS B REACTIVATION
    •CHANGE IN LIVER TESTS
    •RIBAVIRIN RISKS
    •MEDICATION INTERACTIONS
    Common Side Effects for

  • Prices with our coupons for Zepatier vs. Olysio

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