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Olysio
Olysio (simeprevir) is an oral medication that was used with other medications to treat hepatitis C. It is no longer available and has been replaced by newer antiviral medications.
Last reviewed on May 31, 2021
What is Olysio (simeprevir)?
How Olysio (simeprevir) works
Drug Facts
Common BrandsOlysio
Drug ClassAntiviral
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
Frequently asked questions about Olysio (simeprevir)
What is Olysio (simeprevir)?
Olysio (simeprevir) is a antiviral medication that stops hepatitis C virus (HCV) from making copies of itself in your liver. It was not a full regimen on it's own and had to be taken with peginterferon (an injection HCV medication) and ribavirin (another oral medication).
Is Olysio (simeprevir) still available?
No, there are no brand or generic versions available in the U.S.
Why was Olysio (simeprevir) discontinued?
Olysio (simeprevir) had to be taken with 2 medications, peginterferon and ribavirin, which have a lot of side effects. Once newer oral medications with high cure rates were available, people stopped using injectable medications like peginterferon. It's likely the manufacturer stopped making Olysio (simeprevir) due to the lack of demand.
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Interactions between Olysio (simeprevir) and other drugs
Olysio (simeprevir) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Olysio (simeprevir). Please note that only the generic name of each medication is listed below.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abametapir
- Abiraterone Acetate
- Aliskiren
- Ambrisentan
- Amiodarone
- Amprenavir
- Apixaban
- Aprepitant
- Atazanavir
- Atorvastatin
- Boceprevir
- Bosentan
- Ceritinib
- Ciprofloxacin
- Cisapride
- Clarithromycin
- Cobicistat
- Conivaptan
- Crizotinib
- Cyclosporine
- Daclatasvir
- Darunavir
- Delavirdine
- Digoxin
- Diltiazem
- Disopyramide
- Doxorubicin
- Doxorubicin Hydrochloride Liposome
- Dronedarone
- Efavirenz
- Erythromycin
- Etravirine
- Ezetimibe
- Fexofenadine
- Flecainide
- Fluconazole
- Fosamprenavir
- Fosaprepitant
- Fosnetupitant
- Fosphenytoin
- Glyburide
- Idelalisib
- Imatinib
- Indinavir
- Itraconazole
- Ketoconazole
- Lapatinib
- Ledipasvir
- Levomilnacipran
- Loperamide
- Lopinavir
- Methotrexate
- Mexiletine
- Miconazole
- Midazolam
- Mifepristone
- Milk Thistle
- Modafinil
- Morphine
- Morphine Sulfate Liposome
- Nafcillin
- Nateglinide
- Nefazodone
- Nelfinavir
- Netupitant
- Nevirapine
- Nilotinib
- Oxcarbazepine
- Paliperidone
- Phenobarbital
- Phenytoin
- Pixantrone
- Posaconazole
- Primidone
- Propafenone
- Propranolol
- Quinidine
- Ranolazine
- Repaglinide
- Rifampin
- Rifapentine
- Ritonavir
- Rivaroxaban
- Rosuvastatin
- Saquinavir
- Saxagliptin
- Sildenafil
- Silodosin
- Simvastatin
- Sirolimus
- Sitagliptin
- St John's Wort
- Tadalafil
- Talinolol
- Telaprevir
- Telithromycin
- Ticagrelor
- Tipranavir
- Tolvaptan
- Triazolam
- Valsartan
- Vardenafil
- Verapamil
- Vinblastine
- Vincristine
- Vincristine Sulfate Liposome
- Voriconazole
- Warfarin
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