Key takeaways
Simeprevir (Olysio) and ribavirin (Rebetol) are both antiviral medications used to treat hepatitis C. However, they have several differences. Simeprevir is an oral medication that was used in combination with peginterferon and ribavirin, but it has been discontinued due to the availability of newer treatments. Ribavirin, on the other hand, is still available and is used with other antivirals for chronic hepatitis C, including cases with HIV coinfection. Ribavirin is available in generic form, which can be more affordable, and is used in both children and adults. Ribavirin has a range of side effects, including anemia and potential harm to an unborn baby, requiring careful monitoring and use of birth control. Ribavirin is taken twice daily and has some serious interactions, such as with azathioprine, which can lead to serious blood disorders.
