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Zepatier Coupon - Zepatier 50mg/100mg tablet

Zepatier

elbasvir/grazoprevir
Used for Hepatitis C
Used for Hepatitis C

Zepatier (elbasvir / grazoprevir) is a combination medication containing two antiviral medications, elbasvir and grazoprevir. It's one of the first choice treatment options for hepatitis C genotypes 1 and 4.

Reviewed by:
reviewer
Hope Chang, PharmD, AAHIVP
reviewer
Michelle Nguyen, PharmD
Last reviewed on May 3, 2021
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesLatest newsImagesPricesMedicare
basics-icon

What is Zepatier (elbasvir / grazoprevir)?

What is Zepatier (elbasvir / grazoprevir) used for?

  • Hepatitis C infection genotype 1 and 4

How Zepatier (elbasvir / grazoprevir) works

Zepatier (elbasvir / grazoprevir) contains 2 antiviral medications that work together to stop the hepatitis C virus from making copies of itself in the body.

Drug Facts

Common BrandsZepatier
Drug ClassAntiviral Combo
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
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$7175.52
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What are the side effects of Zepatier (elbasvir / grazoprevir)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Fatigue (11%)
  • Headache (10%)

Source: FDA

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Zepatier (elbasvir / grazoprevir)

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Pros

1 tablet once a day is a full regimen for some people and can cure hepatitis C

Doesn't interact with stomach acid medications like Epclusa and Harvoni

Can be taken by people with kidney problems, even those on hemodialysis

Usually has mild side effects

Good option for people taking amiodarone, since it doesn't contain sofosbuvir which can cause slow heartbeat

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Cons

Doesn't treat all the types of hepatitis C like other antiviral combos such as Epclusa or Mavyret

People with hepatitis C type 1 need to have resistance testing before starting therapy

Can't be used in people with cirrhosis or moderate to severe liver problems

Some people who have hepatitis B and C have had their hepatitis B come back after taking hepatitis C treatment

Some people need to take Zepatier (elbasvir / grazoprevir) with an antiviral medication called ribavirin, which can have a lot of side effects

pharmacist-tips

Pharmacist tips for Zepatier (elbasvir / grazoprevir)

pharmacist

  • Take 1 tablet at the same time every day. This will keep the amount of medication in your body consistent and raise your chances of a cure.

    • Zepatier (elbasvir / grazoprevir) comes in a blister pack of individual pills. The tablets are sensitive to moisture so keep the tablets in this package until you are ready to take one.

      • Zepatier (elbasvir / grazoprevir) can interact with other medications. Tell your provider all the medications you are taking. Do not take the herbal supplement St. John's wort while you're taking medications for hepatitis C.

        • If you happen to be hospitalized during your course of heptitis C treatment, make sure you bring your antiviral medications with you to the hospital. Most hospitals do not have hepatitis C medications in stock because they are expensive. They have policies and procedures in place so that your treatment will not be interrupted.

          • Get your labs drawn when your provider instructs you to. This is how they will monitor your liver and make sure the medication is working against the virus. An important lab called "SVR" will be drawn 12 weeks after you have stopped the medication. The results of this lab will determine if you have been cured of hepatitic C.

            faqs

            Frequently asked questions about Zepatier (elbasvir / grazoprevir)

            Does Zepatier (elbasvir / grazoprevir) cure hepatitis C?
            Yes, a successful treatment with Zepatier (elbasvir / grazoprevir) is considered a cure for heptitis C.
            Can hep C come back after taking Zepatier (elbasvir / grazoprevir)?
            It's not likely that heptitis C will come back after achieving "SVR," which is considered a cure. However, treatment of hepatitis C doesn't make you immune to the virus, so it's possible to become reinfected. After treatment it's important to continue to protect yourself from hepatitis C and not receive unclean tattoos or share things like razors and needles.
            Can you drink alcohol while taking Zepatier (elbasvir / grazoprevir)?
            Avoid alcohol while taking Zepatier (elbasvir / grazoprevir). It's not known if alcohol interacts with the medication, but alcohol and hepatitis C can both damage the liver.
            What should I do if I forget a dose of Zepatier (elbasvir / grazoprevir)?
            If you realize you forgot your dose of Zepatier (elbasvir / grazoprevir), take it as soon as you remember unless it's almost time (less than 8 hours) for your next scheduled dose. Never double up on doses.
            When's the best time to take Zepatier (elbasvir / grazoprevir)?
            Zepatier (elbasvir / grazoprevir) can be taken at any time. The most important thing is that you taken the medication at the same time everyday. For people who experience side effects with the medication like a headache, they may prefer to take the medication at night before bedtime so they can sleep through the side effects.
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            What are the risks and warnings for Zepatier (elbasvir / grazoprevir)?

            Zepatier (elbasvir / grazoprevir) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            HEPATITIS B REACTIVATION

            • Risk factors: History of hepatitis B infection

              Some people who have both hepatitis B and C have had their hepatitis B reactivate or flare up after starting treatment for hepatitic C. This can cause liver problems if not caught and treated. You should be tested for hepatitis B before you start Zepatier (elbasvir / grazoprevir). Tell your provider if you've ever had hepatitis B or been treated for it in the past.

              risk-warning

              CHANGE IN LIVER TESTS

              In clinical trials, 1% of people had a large rise in a liver blood test after starting Zepatier (elbasvir / grazoprevir). Your provider will order lab draws for you in order to monitor your liver for this. You might need to stop taking Zepatier (elbasvir / grazoprevir) if your liver test becomes very high. Let your provider know right away if you notice any yellowing of your skin or eyes, stomach pain, loss of appetite, nausea, vomiting, or fatigue.

              risk-warning

              RIBAVIRIN RISKS

              • Risk factors: Taking ribavirin with Zepatier (elbasvir / grazoprevir)

                People with certain types of liver problems may need to take an antiviral medication called ribavirin in addition to Zepatier (elbasvir / grazoprevir). Ribavirin can have a lot of side effects and should not be taken during pregnancy. Make sure to review this medication with your provider and pharmacist before starting your hepatitis C treatment.

                risk-warning

                MEDICATION INTERACTIONS

                Zepatier (elbasvir / grazoprevir) can interact with other medications that might make it not work as well, or raise the risk of side effects. Other medications can also lower the amount of Zepatier (elbasvir / grazoprevir) and lower your chances of a hepatitis C cure. Make sure your providers and pharmacists know all of the medications you're taking, including prescription and over-the-counter medications and herbal supplements. Your provider might have to change your other medications while you're taking Zepatier (elbasvir / grazoprevir).

                dosage

                Zepatier (elbasvir / grazoprevir) dosage forms

                The average cost for 28 tablets of 50mg/100mg of Zepatier (elbasvir / grazoprevir) is $7175.52 with a free GoodRx coupon.0
                tablet
                Tablet
                DosageQuantityPrice as low asPrice per unit
                50mg/100mg28 tablets$7175.52$256.27

                Typical dosing for Zepatier (elbasvir / grazoprevir)

                The recommended dose is 1 tablet once a day with or without food.

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                How much does Zepatier (elbasvir / grazoprevir) cost?

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                Zepatier (brand)
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                alternatives

                What are alternatives to Zepatier (elbasvir / grazoprevir)?

                There are a number of medications that your doctor can prescribe in place of Zepatier (elbasvir / grazoprevir). Compare a few possible alternatives below.
                Zepatier (elbasvir / grazoprevir)
                Used for:

                • Hepatitis C infection genotype 1 and 4

                $7175.52 Lowest GoodRx priceView Prices
                Harvoni (ledipasvir / sofosbuvir)
                Used for:

                • Hepatitis C infection genotype 1, 4, 5, and 6

                $10090.51 Lowest GoodRx priceView Prices
                Sovaldi (sofosbuvir)
                Used for:

                • Hepatitis C infection genotype 1, 2, 3, 4

                $27895.01 Lowest GoodRx priceView Prices
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                Zepatier (elbasvir / grazoprevir) images

                Beige Oval 770 - Zepatier 50mg-100mg Tablet
                This medicine is Beige, Oval Tablet Imprinted With "770".Beige Oval 770 - Zepatier 50mg-100mg Tablet

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