Key takeaways
Naproxen/esomeprazole and Celebrex (celecoxib) are both prescription medications used to treat arthritis, but they have some key differences. Naproxen/esomeprazole is a combination of naproxen, a nonsteroidal anti-inflammatory drug (NSAID), and esomeprazole, a proton pump inhibitor (PPI). This combination helps relieve pain and swelling while protecting your stomach from ulcers. Celebrex, on the other hand, is a COX-2 selective NSAID that specifically targets the COX-2 enzyme involved in pain and inflammation, which generally results in fewer stomach issues compared to other NSAIDs like naproxen. While naproxen/esomeprazole is taken twice a day, Celebrex can be taken once or twice a day depending on the condition being treated. Naproxen/esomeprazole and Celebrex are available as lower-cost generics. Both medications carry risks of serious side effects, including heart attack and stroke, but naproxen/esomeprazole has additional risks due to its esomeprazole component, such as nutrient imbalances and bone fractures. Naproxen/esomeprazole and Celebrex should be avoided if you have kidney problems.
