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Compare Ubrelvy vs. Zolmitriptan

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ubrelvy (ubrogepant) and Zomig (zolmitriptan) are both medications used to treat migraine attacks in adults. However, they belong to different medication classes. Ubrelvy is a calcitonin gene-related peptide (CGRP) receptor blocker, while Zomig is a triptan. Ubrelvy is taken orally and is available only as a brand-name medication, whereas Zomig is available in oral tablets, orally disintegrating tablets, and nasal spray forms, with both brand-name and generic options. Ubrelvy can be taken with or without food. Zomig should be taken at the first sign of a migraine, and its nasal spray form is suitable for those who have trouble swallowing pills. Common side effects of Ubrelvy include nausea, sleepiness, and dry mouth, while Zomig can cause dizziness, nausea, and chest pain. Ubrelvy interacts with many medications, including certain antibiotics and seizure medications, while Zomig can interact with medications that raise serotonin levels, increasing the risk of serotonin syndrome.

  • Ubrelvy (ubrogepant)
    Zolmitriptan (Zomig)
  • Ubrelvy (ubrogepant)
    Zolmitriptan (Zomig)

  • Summary of Ubrelvy vs. Zolmitriptan

    Summary for Calcitonin gene-related peptide (CGRP) receptor antagonist
    Prescription only

    Ubrelvy (ubrogepant) is a migraine medication called a calcitonin gene-related peptide (CGRP) receptor antagonist. It can treat sudden migraine attacks in adults. Ubrelvy (ubrogepant) is a tablet you take by mouth. You take one dose when you feel a migraine starting. If needed, you can take a second dose at least 2 hours later. Your dose depends if Ubrelvy (ubrogepant) interacts with the other medications you take. Side effects include nausea and tiredness.

    Summary for Triptan
    Prescription only

    Zolmitriptan (Zomig) is used for the short-term treatment of migraines. You typically take just one dose when you have a migraine. Zolmitriptan (Zomig) can cause side effects like dizziness and chest, neck, or jaw pain. This medication is a tablet that you swallow. It also comes as an orally disintegrating tablet (ODT) and a nasal spray, which can be good options for people who have trouble swallowing pills during a migraine. Zolmitriptan (Zomig) is available by prescription only as a brand-name and generic medication; it's not found over the counter.

  • Indications of Ubrelvy vs. Zolmitriptan

    Indications for
    •Treatment of migraine attacks with or without aura in adults
    Indications for
    •Treatment of migraine

  • Pros and Cons of Ubrelvy vs. Zolmitriptan

    Pros and Const for Calcitonin gene-related peptide (CGRP) receptor antagonist
    Pros
    •A tablet that's taken by mouth
    •Helps treat sudden migraine attacks
    •Good option when triptans like sumatriptan (Imitrex) haven't worked well
    Cons
    •Takes 1 to 2 hours to start working
    •Not for preventing migraines
    •Can interact with other medications, like verapamil and phenobarbital
    Pros and Const for Triptan
    Pros
    •One of the first-choice options for adults to treat moderate or severe migraine
    •Works within 2 hours after taking the dose
    •Has ODT and nasal spray forms, so it's a good option for people who have trouble swallowing pills during a migraine
    Cons
    •Not used for other types of headaches
    •Doesn't prevent migraines from happening
    •Can worsen your headaches if you take the medication for more than 9 days in a month

  • Common Side Effects of Ubrelvy vs. Zolmitriptan

    Common Side Effects for
    •Nausea (up to 4%)
    •Sleepiness (up to 3%)
    •Dry mouth (up to 2%)
    Common Side Effects for

    Tablets and orally disintegrating tablets

    •Nausea (up to 9%)
    •Dizziness (up to 8%)
    •Pins and needles feeling in the arms or legs (up to 7%)
    •Neck, throat, or jaw pain, tightness, or pressure (up to 7%)
    •Sleepiness (up to 6%)
    •Feeling warm or cold (up to 6%)
    •Body weakness (up to 5%)
    •Dry mouth (up to 5%)
    •Chest pain, tightness, pressure, or heaviness (up to 3%)

    Nasal spray

    •Unusual taste (up to 17%)
    •Dizziness (6%)
    •Pins and needles feeling in your arms or legs (5%)
    •Throat pain (4%)
    •Feeling warm (4%)
    •Dry mouth (3%)
    •Body weakness (3%)

  • Warnings of Ubrelvy vs. Zolmitriptan

    Common Side Effects for
    •Allergic reactions
    •High blood pressure
    •Raynaud's phenomenon
    Common Side Effects for
    •Heart attack and chest pain (angina)
    •Irregular heart rhythm (arrhythmias)
    •Stroke or other brain injury
    •Blood vessel issues
    •Serotonin syndrome
    •High blood pressure
    •Caution use in people with phenylketonuria (PKU) - for orally disintegrating tablet only

  • Prices with our coupons for Ubrelvy vs. Zolmitriptan

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    Learn more about Zolmitriptan

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