Key takeaways
Trintellix (vortioxetine) and Cymbalta (duloxetine) are both medications used to treat depression, but they belong to different drug classes. Trintellix is an atypical antidepressant, while Cymbalta is an SNRI (serotonin and norepinephrine reuptake inhibitor). Trintellix is taken once daily and is not available in a generic form, whereas Cymbalta can be taken once or twice daily and is available as a lower-cost generic. Trintellix primarily affects serotonin levels, while Cymbalta affects both serotonin and norepinephrine, making it useful for treating anxiety and various types of long-term pain, including diabetic neuropathy and fibromyalgia. Both medications can cause nausea and have a risk of withdrawal symptoms if stopped abruptly, but Cymbalta also has a higher risk of liver damage and can affect blood pressure. Trintellix might be less likely to cause weight gain compared to other antidepressants, while Cymbalta can cause either weight gain and weight loss.
