Striant vs. Aveed for Testosterone Replacement: Important Differences and Potential Risks.

Key takeaways

Testosterone oral tablet (Striant) and testosterone undecanoate injection (Aveed) are both testosterone replacement therapies used to treat low testosterone in adult males. However, they differ in several ways. Striant, which is no longer available in the U.S., was an orally dissolving tablet. Aveed is an injectable form that must be administered by a healthcare professional. Aveed requires a Risk Evaluation and Mitigation Strategy (REMS) due to serious risks, such as pulmonary oil microembolism (POME) and severe allergic reactions. Aveed is typically injected every 10 weeks after the initial doses, whereas Striant was a daily oral medication. Common side effects of Aveed include acne and injection site pain, while it also carries risks of serious side effects like heart attack and stroke. Additionally, Aveed can interact with blood thinners, potentially increasing bleeding risks.

testosterone oral tablet

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Aveed

(testosterone undecanoate)

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Summary for Striant

Discontinued

The testosterone oral tablet is used to treat low testosterone in adult males. It's no longer available in the United States because it was discontinued.

Pros and Cons for Striant

Pros

Cons

Summary for Aveed

Prescription only

Aveed (testosterone undecanoate) is an injectable testosterone that’s used to treat low testosterone in adult males. It's an FDA-approved testosterone replacement therapy that must be injected by a healthcare professional due to possible allergic reactions and a serious warning called pulmonary oil microembolism (POME), which causes symptoms such as coughing, chest pain, and trouble breathing. Initially, you'll receive the first two injections a month apart, then an injection every 10 weeks after that. Common side effects include acne, pain at the injection site, and fatigue.

Indications for Aveed

Low testosterone (also called hypogonadism)

Pros and Cons for Aveed

Pros

Works well to replace testosterone in your body
Can be given every 10 weeks (after the first 2 injections)
No accidental testosterone exposure to another person through skin-to-skin contact like testosterone gels