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Compare Savella vs. Cymbalta

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Savella (milnacipran)
    Duloxetine (Cymbalta)
  • Savella (milnacipran)
    Duloxetine (Cymbalta)

  • Summary of Savella vs. Cymbalta

    Summary for Serotonin and norepinephrine reuptake inhibitor (SNRI)
    Prescription only

    Savella (milnacipran) is FDA approved to manage fibromyalgia in adults. It belongs to the drug class called serotonin and norepinephrine reuptake inhibitors (SNRIs). Savella (milnacipran) is a tablet that's taken by mouth twice a day. You'll usually follow a dosing schedule for the first few days to reach the right dose for you. Side effects can include nausea, constipation, headache, and dizziness. As of January 2025, Savella (milnacipran) is only available as a brand-name medication. There's no generic version yet.

    Summary for SNRI
    Prescription only

    Duloxetine (Cymbalta) helps treat depression and anxiety. It can also help with some types of chronic pain, such as nerve pain from diabetes. Duloxetine (Cymbalta) is a type of antidepressant called an SNRI, or serotonin and norepinephrine reuptake inhibitor. Most people take it by mouth once a day, but some with depression might take it twice a day. Side effects include nausea, headache, and dry mouth. When it's time to stop taking the medication, the prescriber will slowly lower your dose to help prevent withdrawal symptoms.

  • Indications of Savella vs. Cymbalta

    Indications for
    •Fibromyalgia
    Indications for
    •Depression in adults
    •Generalized anxiety disorder in people ages 7 years and older
    •Diabetic neuropathy (nerve pain caused by high blood sugar) in adults
    •Fibromyalgia in people ages 13 years and older
    •Chronic pain in the muscles, bones, joints, or tendons in adults

  • Pros and Cons of Savella vs. Cymbalta

    Pros and Const for Serotonin and norepinephrine reuptake inhibitor (SNRI)
    Pros
    •One of few medications approved for fibromyalgia
    •Can take with or without food
    Cons
    •Taken every day to help with fibromyalgia pain over time, not just "as needed" for quick relief
    •Not approved for children
    Pros and Const for SNRI
    Pros
    •Taken once a day for most people
    •Can take at any time of day
    •A first-choice option for depression
    •An option for some types of chronic pain, like nerve pain from diabetes
    Cons
    •Can take several weeks before you feel its full effects
    •Might not be a good option for people who drink heavily or have liver or kidney problems
    •Can cause nausea or dry mouth
    •Can interact with many medications, including other antidepressants and certain pain relievers

  • Common Side Effects of Savella vs. Cymbalta

    Common Side Effects for
    •Nausea (37%)
    •Headache (18%)
    •Constipation (16%)
    •Trouble falling and staying asleep (insomnia, 12%)
    •Sudden feeling of warmth (hot flush, 12%)
    •Dizziness (10%)
    Common Side Effects for
    •Nausea (23%)
    •Headache (14%)
    •Dry mouth (13%)
    •Drowsiness (10%)
    •Feeling tired (9%)
    •Trouble sleeping (9%)
    •Dizziness (9%)
    •Constipation (9%)
    •Diarrhea (9%)
    •Low appetite (7%)
    •A lot of sweating (6%)
    •Stomach pain (5%)

  • Warnings of Savella vs. Cymbalta

    Common Side Effects for
    •Suicidal thoughts and behavior
    •Serotonin syndrome
    •Higher blood pressure and faster heart rate
    •Higher risk of bleeding
    •Urination problems
    •Sexual problems
    •Liver damage
    •Worsening of glaucoma in certain people
    Common Side Effects for
    •Suicidal thoughts or behavior
    •Liver damage
    •Changes in blood pressure and risk of falls
    •Serotonin syndrome
    •Higher risk of bleeding
    •Severe skin reaction
    •Withdrawal symptoms
    •Low sodium levels
    •Sexual problems
    •Not for use alone for bipolar disorder because of the risk of mania
    •Angle-closure glaucoma in certain people

  • Prices with our coupons for Savella vs. Cymbalta

    Learn more about Savella
    Learn more about Duloxetine

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