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Savella vs. Cymbalta

Savella (milnacipran) is FDA approved to manage fibromyalgia in adults. It belongs to the drug class called serotonin and norepinephrine reuptake inhibitors (SNRIs). Savella (milnacipran) is a tablet that's taken by mouth twice a day. You'll usually follow a dosing schedule for the first few days to reach the right dose for you. Side effects can include nausea, constipation, headache, and dizziness. As of January 2025, Savella (milnacipran) is only available as a brand-name medication. There's no generic version yet.

• Fibromyalgia

• Nausea (37%)
• Headache (18%)
• Constipation (16%)
• Trouble falling and staying asleep (insomnia, 12%)
• Sudden feeling of warmth (hot flush, 12%)
• Dizziness (10%)

• Suicidal thoughts and behavior
• Serotonin syndrome
• Higher blood pressure and faster heart rate
• Higher risk of bleeding
• Urination problems
• Sexual problems
• Liver damage
• Worsening of glaucoma in certain people

Duloxetine (Cymbalta) helps treat depression and anxiety. It can also help with some types of chronic pain, such as nerve pain from diabetes. Duloxetine (Cymbalta) is a type of antidepressant called an SNRI, or serotonin and norepinephrine reuptake inhibitor. Most people take it by mouth once a day, but some with depression might take it twice a day. Side effects include nausea, headache, and dry mouth. When it's time to stop taking the medication, the prescriber will slowly lower your dose to help prevent withdrawal symptoms.

• Depression in adults
• Generalized anxiety disorder in people ages 7 years and older
• Diabetic neuropathy (nerve pain caused by high blood sugar) in adults
• Fibromyalgia in people ages 13 years and older
• Chronic pain in the muscles, bones, joints, or tendons in adults

• Nausea (23%)
• Headache (14%)
• Dry mouth (13%)
• Drowsiness (10%)
• Feeling tired (9%)
• Trouble sleeping (9%)
• Dizziness (9%)
• Constipation (9%)
• Diarrhea (9%)
• Low appetite (7%)
• A lot of sweating (6%)
• Stomach pain (5%)

• Suicidal thoughts or behavior
• Liver damage
• Changes in blood pressure and risk of falls
• Serotonin syndrome
• Higher risk of bleeding
• Severe skin reaction
• Withdrawal symptoms
• Low sodium levels
• Sexual problems
• Not for use alone for bipolar disorder because of the risk of mania
• Angle-closure glaucoma in certain people