Key takeaways
Renova (tretinoin) and Differin (adapalene) are both topical retinoids used for skin care, but they have different primary uses and availability. Renova is mainly prescribed to lessen fine wrinkles and improve skin appearance, while Differin is primarily used to treat mild-to-moderate acne. Renova requires a prescription, whereas Differin is available both over-the-counter and by prescription, depending on the strength. Both medications can cause skin irritation, redness, and peelin. Renova isn’t safe for use during pregnancy, and Differin should be used with caution if you are pregnant or breastfeeding. Additionally, Renova may take 3 to 4 months to show full effects, while Differin can take up to 12 weeks. Both medications make your skin more sensitive to the sun, so you should use sunscreen and protective clothing while using them.
