Key takeaways
Nabumetone (Relafen) and Tylenol with Codeine (acetaminophen/codeine) are both used to relieve pain, but they work in different ways and are used for different types of pain. Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) that helps with arthritis symptoms like joint pain, swelling, and stiffness. It is usually taken once or twice a day and is less likely to cause stomach-related side effects compared to some other NSAIDs. On the other hand, Tylenol with Codeine is a combination of acetaminophen and codeine, an opioid, used for mild-to-moderate pain that non-opioid medications can't relieve. It is taken every 4 hours as needed and can be habit-forming, with risks of dependence and dangerous breathing problems. While nabumetone is not a controlled substance, Tylenol with Codeine is a Schedule III controlled substance due to its potential for misuse. Both medications are available only by prescription, but Tylenol with Codeine also comes in a liquid form for those who have trouble swallowing tablets.
