Key takeaways
Medroxyprogesterone (Provera) and Depo-Estradiol (estradiol cypionate) are both prescription medications, but they serve different purposes and are administered differently. Medroxyprogesterone is a progestin taken orally to regulate menstrual cycles and protect the uterus from damage in postmenopausal women on estrogen replacement therapy. In contrast, Depo-Estradiol is an estrogen therapy given as an injection into the muscle to treat low estrogen conditions and severe menopausal symptoms like hot flashes and night sweats. Medroxyprogesterone is available in generic form, while Depo-Estradiol is only available as a brand-name injection. Medroxyprogesterone is taken daily for a specific number of days each month, whereas Depo-Estradiol is typically injected once a month. Depo-Estradiol requires the use of a progestin medication if you still have your uterus to lower the risk of uterine cancer, while medroxyprogesterone itself helps mitigate this risk when taken with estrogen. Both medications carry risks of serious side effects, including blood clots and certain cancers. However, Depo-Estradiol also has specific risks, like gallbladder problems and high blood calcium levels.
