Key takeaways
Desvenlafaxine (Pristiq) and bupropion (Wellbutrin XL, Wellbutrin SR, Forfivo XL) are both medications used to treat depression. However, they belong to different medication classes. Desvenlafaxine is a serotonin and norepinephrine reuptake inhibitor (SNRI), while bupropion is an atypical antidepressant. Desvenlafaxine is only approved for depression, whereas bupropion is also approved for seasonal affective disorder (SAD) in its extended-release form. Desvenlafaxine is typically taken once daily as a tablet, while bupropion is available in various forms, including short-acting tablets taken multiple times a day and long-acting versions taken once daily. Both medications are available in lower-cost generic forms. Desvenlafaxine may cause side effects like nausea and dizziness, and it can raise blood pressure. Bupropion is less likely to cause sexual side effects and weight gain but can increase the risk of seizures, especially in people with a history of seizures or eating disorders. Both medications can cause suicidal thoughts, especially in younger people, and should not be stopped suddenly without consulting a healthcare professional to avoid withdrawal symptoms.
