Key takeaways
Premarin (conjugated estrogens) is available in two forms: oral tablets and vaginal cream. The oral tablets are used to treat a variety of conditions, including menopausal symptoms like hot flashes and vaginal dryness, low estrogen levels due to other conditions, certain cancers in advanced stages, and to prevent bone loss after menopause. In contrast, Premarin vaginal cream is specifically used to treat vaginal symptoms due to menopause, such as vaginal dryness and pain during sex. The oral tablets are taken by mouth and can be used daily or in cycles, while the vaginal cream is applied directly into the vagina either daily in cycles or twice a week. Both forms can cause side effects like headaches and breast pain, but the oral tablets have a broader range of potential side effects and risks, including a higher chance of blood clots, strokes, and certain cancers. The vaginal cream is less likely to be absorbed into the body as much as the oral tablets, which may reduce some risks. Both forms are brand-name medications and do not have generic versions.
