Key takeaways
Odefsey (emtricitabine/rilpivirine/tenofovir alafenamide) and Complera (emtricitabine/rilpivirine/tenofovir disoproxil fumarate) are both single-tablet regimens used to treat HIV. The main difference between the two is the form of tenofovir they contain. Odefsey has tenofovir alafenamide, which is newer and causes fewer harmful effects on your kidneys and bones compared to the tenofovir disoproxil fumarate in Complera. Both medications need to be taken with a meal at least 400 calories. Complera is no longer a first-choice treatment due to the availability of newer medications with fewer side effects, whereas Odefsey is considered safer for long-term use. Both medications have similar side effects, such as headaches and sleep problems, but Odefsey is noted to cause fewer abnormal dreams. Additionally, Complera has been used more often in pregnant individuals, although both can be taken during pregnancy.
