Key takeaways
Naproxen (Naprosyn) and acetaminophen (Tylenol) are both used to relieve pain, but they work differently and have different uses. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that helps with pain and inflammation by blocking proteins called COX. It's often used for conditions like arthritis, gout, and menstrual cramps. Acetaminophen, on the other hand, is an analgesic that reduces pain and fever but doesn't help with inflammation. It's not fully understood how acetaminophen works, but it's thought to affect chemicals in the brain and nervous system. Naprosyn is available by prescription (although other naproxen products are available over-the-counter, or OTC), while acetaminophen can be bought OTC. Naproxen can cause side effects like stomach pain and heartburn, and it may raise blood pressure. Acetaminophen generally has fewer side effects but can cause serious liver damage if taken in high doses or with alcohol. Both medications come in various forms, but naproxen is typically taken 2 times a day, while acetaminophen is taken every 4 to 6 hours.
