Key takeaways
Naproxen (Aleve, Naprosyn) and acetaminophen / codeine (Tylenol #3) are pain medications. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Most forms are available over the counter. Tylenol #3 considered an opioid because it contains codeine, but it also contains acetaminophen (Tylenol). Usually, non-opioid medications such as naproxen are tried first for mild-to-moderate pain. If they don’t work, an opioid such as Tylenol #3 may be tried. Common naproxen side effects include nausea and heartburn. More serious risks include stomach ulcers or bleeding, and kidney damage. NSAIDs, such as naproxen, can also raise your risk of a heart attack. Tylenol #3 side effects include drowsiness, nausea, and constipation. More serious risks include misuse, overdose, and liver damage.
