Key takeaways
Nabumetone (Relafen) and meloxicam (Mobic, Anjeso) are both prescription nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat pain and inflammation associated with arthritis. They share similar FDA-approved uses for conditions like osteoarthritis and rheumatoid arthritis. However, meloxicam is also approved for juvenile rheumatoid arthritis and moderate-to-severe pain when given as an injection. Nabumetone is typically taken as an oral tablet once or twice daily, whereas meloxicam is available in various forms, including capsules, tablets, oral suspension, and injection, and is typically taken once daily. Both medications are available as a lower-cost generic. Common side effects for both include stomach upset and diarrhea and carry risks of serious side effects like heart attack, stroke, and stomach bleeding. They should not be combined with other NSAIDs and are not recommended during pregnancy.
