Key takeaways
Metronidazole topical (Metrogel) and metronidazole (Flagyl) contain the same antibiotic but are used to treat different conditions. Metrogel is used topically to treat rosacea. Flagyl, on the other hand, is taken orally or by injection to treat various bacterial and parasitic infections. While Metrogel is applied as a thin film once daily, Flagyl is typically taken by mouth or injection three times a day, with dosing varying based on the infection. Metrogel is available in gel, lotion, and cream forms, while Flagyl comes in immediate-release and extended-release tablets and capsules. Both medications are available as generics. Common side effects of Metrogel include nasopharyngitis and headaches, whereas Flagyl can cause nausea, a metallic taste, and headaches. You should avoid alcohol with Flagyl due to the risk of serious interactions, a concern not present with Metrogel.
