Key takeaways
Methotrexate (Otrexup, Rasuvo) and sulfasalazine (Azulfidine) are both used to treat rheumatoid arthritis (RA), but they have different uses and ways of working. Methotrexate is an antimetabolite that treats various cancers and non-cancer conditions like RA and psoriasis. It is given as an injection or may be taken by mouth as a tablet and works by blocking a protein important for cell growth. Sulfasalazine, on the other hand, is an anti-inflammatory medication available in immediate-release and delayed-release tablets. It treats ulcerative colitis (UC) and RA by breaking down into chemicals that reduce inflammation. Methotrexate can cause serious side effects like low white blood cells and kidney problems, while sulfasalazine commonly causes stomach issues like nausea and indigestion. Methotrexate is not safe during pregnancy, whereas sulfasalazine might not be safe for people with allergies to sulfa drugs. Both medications require regular monitoring by your healthcare provider to ensure safety and effectiveness.
