Key takeaways
Methadone (Methadose, Methadone HCl Intensol) and fentanyl (formerly branded as Duragesic) are both opioids used to manage severe pain, but they have some key differences. Methadone is available in oral forms like tablets and liquids, while fentanyl is used as a transdermal patch. Methadone is also used to treat opioid use disorder (OUD) and requires supervision at a methadone clinic initially, whereas fentanyl is only for those already taking opioids around-the-clock. Methadone can be habit-forming and has a risk of life-threatening slow breathing, similar to fentanyl, which also carries risks of addiction, misuse, and overdose. Fentanyl patches need to be changed every 72 hours and can be worn while showering, but exposure to heat can increase the risk of overdose. Both medications have serious side effects, including the potential for life-threatening breathing problems and withdrawal symptoms in newborns if used during pregnancy.
