Key takeaways
Gemfibrozil (Lopid) and omega-3-acid ethyl esters (Lovaza) are both used to lower triglycerides, but they work differently and have different uses. Gemfibrozil is a fibrate that helps break down fats and lowers the production of certain fats in your liver, while omega-3-acid ethyl esters contain omega-3 fatty acids (EPA and DHA) and their exact mechanism isn't well understood. Gemfibrozil is taken twice a day before meals, whereas omega-3-acid ethyl esters can be taken once or twice a day with food. Common side effects of gemfibrozil include indigestion and stomach pain, while omega-3-acid ethyl esters can cause burping and changes in taste. Gemfibrozil has many interactions with other medications, especially statins, and isn't recommended for people with liver, kidney, or gallbladder problems. On the other hand, omega-3-acid ethyl esters might not be suitable for people with fish or shellfish allergies and can raise the risk of irregular heart rhythms. Both medications are available as lower-cost generics.
