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Lodine vs. Tylenol With Codeine

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Etodolac (formerly known as Lodine) and Tylenol with Codeine (acetaminophen/codeine) are prescription medications used to treat pain. In addtition to treating pain, they also have several differences between them. Unlike Tylenol with Codeine, etodolac helps reduce inflammation and is available in immediate-release and extended-release forms. Tylenol with Codeine is used to help reduce mild-to-moderate pain, while etodolac is approved to treat arthritis pain. Etodolac doesn't have a risk for dependence and misuse like Tylenol with Codeine. Both medications have potential side effects, but Tylenol with Codeine carries more severe risks, such as dangerously slow breathing and accidental overdose.

Etodolac

 

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Tylenol with Codeine

 

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Summary for Lodine

Prescription only

Etodolac, also known by its brand name Lodine, is a non-steroidal anti-inflammatory drug (NSAID). The immediate-release pills are taken throughout the day; they're approved for adults with sudden, short-term pain; rheumatoid arthritis; or osteoarthritis. There's also an extended-release tablet for people ages 6 years and older that's taken once per day for the same types of arthritis. Side effects can include stomach pain, dizziness, and rash. Etodolac is currently available by prescription as generic only; the brand name has been discontinued.

Indications for Lodine

Pros and Cons for Lodine

Pros

  • Works well to treat pain and inflammation
  • Extended-release tablets can be used for children as young as 6 years old
  • Available as a lower-cost generic

Cons

  • Only available as pills that can't be split, open, or crushed
  • Not safe to take after 20 weeks of pregnancy
  • Might not be the best option if you're 65 years or older or if you have kidney, heart, liver, or bleeding problems

Common Side Effects for Lodine

The following side effects were reported in 1% to 10% of people who took etodolac:

Warnings for Lodine

  • Stomach bleeding
  • Heart attack and stroke
  • High blood pressure and heart failure
  • Kidney damage
  • Liver problems
  • Severe allergic reactions and skin reactions
  • Not safe to take while pregnant
  • Risk for bleeding

Summary for Tylenol With Codeine

Prescription only

Tylenol with Codeine (acetaminophen / codeine), also known as Tylenol #3, is a combination opioid medication. Both acetaminophen and codeine treat mild-to-moderate pain by blocking pain signals in the body. This medication is taken by mouth, typically every 4 hours as needed. Tylenol with Codeine is available as a tablet and liquid. Like other opioids, Tylenol with Codeine can cause common side effects like sleepiness, dizziness, and constipation. It also has a warning for dangerous breathing problems and risk of dependence and misuse.

Indications for Tylenol With Codeine

Pros and Cons for Tylenol With Codeine

Pros

  • Works well for treating mild-to-moderate pain
  • Combines 2 medications with different modes of pain relief into a single pill
  • Available in a liquid form for people who have trouble swallowing tablets
  • Available as a generic medication

Cons

  • For short-term pain relief only
  • Can be habit-forming
  • Not recommended to take with other medications containing acetaminophen, since it can raise the risk of liver damage
  • Liquid solution contains alcohol

Common Side Effects for Tylenol With Codeine

  • Drowsiness
  • Lightheadedness
  • Dizziness
  • Sleepiness
  • Trouble breathing
  • Nausea
  • Vomiting
  • Constipation
  • Sweating

Warnings for Tylenol With Codeine

  • Potential for dependence and misuse
  • Dangerously slow breathing (respiratory depression)
  • Risk of accidental overdose
  • Harm to newborn babies
  • Serious medication interactions
  • Difficulty concentrating and extreme sleepiness
  • Liver damage
  • Severe allergic and skin reactions
  • Seizures
  • Low blood pressure
  • Low adrenal hormone levels
  • Caution in certain medical conditions
  • Withdrawal

Prices with our coupons for Lodine vs. Tylenol With Codeine

Price Card Drug Icon
Etodolac60 tablets / 400mg
$25.84$78.73
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Price Card Drug Icon
Acetaminophen/Codeine30 tablets / 300mg/30mg
$17.33$51.79
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