Key takeaways
Intrarosa (prasterone) and Divigel (estradiol) are both medications used to treat symptoms related to menopause, but they work differently and have different uses. Intrarosa is a synthetic form of DHEA that's inserted vaginally to relieve painful intercourse due to menopause. Divigel, on the other hand, is an estrogen replacement therapy applied as a gel to the skin to treat hot flashes and night sweats. Intrarosa is used once daily at bedtime, while Divigel is applied once daily to the upper thigh. Intrarosa is only available as a brand-name medication, whereas Divigel is available in both brand-name and generic forms. Common side effects of Intrarosa include vaginal discharge, while Divigel can cause vaginal yeast infections and breast tenderness. Divigel carries a risk of serious side effects like blood clots and certain cancers, which are not associated with Intrarosa. You'll also need to take a progestin along with Divigel in most cases, which isn't required with Intrarosa. Additionally, Divigel can transfer to others through skin contact, so you need to be careful after applying it.
