Key takeaways
Azathioprine (Imuran, Azasan) and prednisone (Rayos, Prednisone Intensol) are both prescription medications used to manage conditions related to the immune system, but they belong to different drug classes and have distinct uses and side effects. Azathioprine is an immunosuppressant often used after kidney transplants and for rheumatoid arthritis, while prednisone is a corticosteroid used for a wide range of conditions, including allergies, skin conditions, and certain cancers. Azathioprine works by weakening your immune response to prevent organ rejection or reduce joint inflammation, whereas prednisone mimics cortisol to reduce inflammation and immune activity. Azathioprine requires regular blood tests and has a higher risk of causing infections and certain cancers with long-term use. Prednisone, on the other hand, can cause mood changes, weight gain, and bone weakening if used for a long time. Both medications should be taken with food to reduce stomach irritation, and you should avoid alcohol while taking them. Both medications are available in a generic form, making them more affordable. Azathioprine is available in tablet form, while prednisone is available in various forms, including a liquid option for those who have trouble swallowing pills.
