Key takeaways
Ibsrela (tenapanor) and Bentyl (dicyclomine) are both used to treat irritable bowel syndrome (IBS), but they work in different ways and treat different types of IBS. Ibsrela is specifically for IBS with constipation (IBS-C) and works by preventing sodium absorption in the gut, which helps soften stool and relieve constipation. Additionally, Ibsrela works on the nerves in the gut to relieve stomach pain. It is taken as a tablet twice a day before meals. Common side effects include diarrhea, bloating, and gas. On the other hand, Bentyl is an anticholinergic medication used to treat muscle spasms in the stomach and intestines for general IBS. It helps relax gut muscles by blocking acetylcholine from attaching to receptors in the gut and is taken four times a day. Common side effects include dizziness, dry mouth, and blurred vision. Bentyl is available in generic form and also as an injection for those who can't take oral medication, unlike Ibsrela which is only available in the oral dosage form and as a brand-name medication. Ibsrela is not recommended for children, while Bentyl is not suitable for people with certain heart conditions, glaucoma, or those who are breastfeeding.
