Key takeaways
Hectorol (doxercalciferol) and Sensipar (cinacalcet) are both used to manage parathyroid hormone (PTH) levels, but they work differently and are used for different conditions. Hectorol (doxercalciferol) is a vitamin D analog that helps lower PTH levels by increasing calcium absorption, which in turn reduces PTH production. It is used specifically for people with chronic kidney disease (CKD) and is available as both capsules and intravenous injections. On the other hand, Sensipar (cinacalcet) is a calcimimetic that directly lowers PTH levels by making the parathyroid gland more sensitive to calcium, thus reducing PTH production. Sensipar (cinacalcet) is used for overactive parathyroid conditions, including those caused by parathyroid cancer, and is taken orally with food. While both medications are available in generic forms, Hectorol (doxercalciferol) can cause high calcium levels, whereas Sensipar (cinacalcet) can cause calcium levels to drop too low. Additionally, Sensipar (cinacalcet) is not the first choice for treating high PTH levels and requires careful monitoring for potential heart and gastrointestinal issues.
