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Genvoya vs. Complera

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) and Complera (emtricitabine/rilpivirine/tenofovir disoproxil fumarate) are both combination treatments for HIV, but they have some key differences. Genvoya includes four medications: two NRTIs (emtricitabine and tenofovir alafenamide), an INSTI (elvitegravir), and a booster (cobicistat). Complera, on the other hand, contains three medications: two NRTIs (emtricitabine and tenofovir disoproxil fumarate) and an NNRTI (rilpivirine). Both medications are not available in generic forms. Genvoya is taken once daily with food, while Complera also requires food but specifies a meal of at least 400 calories and is not a first-choice treatment due to newer options with fewer side effects. Complera can be used during pregnancy, whereas Genvoya cannot. Both medications have similar side effects like nausea and headaches, but Complera is more associated with mood changes and depression. Additionally, Genvoya has a booster to enhance the effectiveness of its components, which Complera lacks.

Genvoya

 

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Complera

 

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Summary for Genvoya

Prescription only

Genvoya (elvitegravir / cobicistat / emtricitabine / tenofovir alafenamide) is a combination antiretroviral therapy (ART) that treats human immunodeficiency virus (HIV) infections in adults and children. It's made up of two nucleoside reverse transcriptase inhibitors (NRTIs), emtricitabine and tenofovir alafenamide; an integrase strand transfer inhibitor (INSTI) called elvitegravir; and a "booster" medication known as cobicistat. Genvoya is taken by mouth, typically once daily. Some common side effects of this medication include nausea and diarrhea. It's not available as a generic medication.

Indications for Genvoya

Pros and Cons for Genvoya

Pros

  • Is a complete regimen for HIV treatment
  • Only taken once a day
  • Taken by mouth

Cons

  • Needs to be taken with food
  • Can’t take while pregnant
  • Can worsen hepatitis B if you stop taking the medication all of a sudden

Common Side Effects for Genvoya

  • Nausea (11%)
  • Diarrhea (7%)
  • Headache (6%)
  • Feeling tired (5%)

Warnings for Genvoya

  • Worsening of hepatitis B infection
  • Kidney problems
  • Liver problems and lactic acidosis
  • Overactive immune system
  • Interaction with other medications

Summary for Complera

Prescription only

Complera is a single-tablet regimen containing 3 HIV antiretrovirals (ARVs), rilpivirine (Edurant), emtricitabine (Emtriva), and tenofovir disoproxil fumarate (Viread). It's no longer a first-choice treatment option due to newer agents with fewer side effects.

Indications for Complera

  • HIV treatment

Pros and Cons for Complera

Pros

  • 1 tablet once a day is a full HIV regimen
  • Can be used in pregnancy at the same dose
  • Contains tenofovir, which is also a first-choice treatment option for hepatitis B
  • Causes less abnormal dreams when compared to a similar medication Atripla
  • Not associated with weight gain

Cons

  • Must be taken with food
  • Not recommended for people with kidney problems since the dose can't be adjusted
  • Can't be used if the amount of virus (viral load) is too high
  • There are many medication interactions and it can't be taken with some medications used to treat tuberculosis, seizures, and stomach acid.
  • Can lead to kidney and bone problems

Common Side Effects for Complera

  • Change in mood, depression (2%)
  • Headache (2%)
  • Trouble sleeping, insomnia (2%)

Warnings for Complera

  • WORSENING OF HEPATITIS B
  • LIVER PROBLEMS AND TOXICITY
  • DEPRESSION AND CHANGES IN MOOD
  • KIDNEY PROBLEMS
  • BONE PROBLEMS
  • IMMUNE RECONSTITUTION SYNDROME

Prices with our coupons for Genvoya vs. Complera

Price Card Drug Icon
Genvoya30 tablets / 150mg/150mg/200mg/10mg
$3,872.52$5,474.00
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Price Card Drug Icon
Emtricitabine/Rilpivirine/Tenofovir30 tablets / 200mg/25mg/300mg of
$956.64$3,040.49
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