Key takeaways
Piroxicam (Feldene) and acetaminophen (Tylenol) are both used to relieve pain, but they work differently and are used for different types of pain. Piroxicam is a prescription nonsteroidal anti-inflammatory drug (NSAID) that helps with arthritis pain by reducing inflammation (swelling). Acetaminophen isn't typically used to reduce inflammation, but it's available over-the-counter (OTC) to help lower fever and relieve mild pain. Piroxicam is taken once daily and can take up to 2-3 months to feel the full effects, whereas acetaminophen works within 45 minutes and is taken every 4-6 hours as needed. Piroxicam can cause serious side effects like stomach bleeding and heart problems, especially if taken for a long time, while acetaminophen's main risk is liver damage, particularly if you drink alcohol or take too much. Piroxicam isn't recommended in people who are pregnant; however, acetaminophen is generally considered safe during pregnancy and breastfeeding.
