Skip to main content

Compare
Farxiga vs. Rybelsus

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Farxiga (dapagliflozin) and Rybelsus (semaglutide) are used to treat Type 2 diabetes, but there are several differences between the two medications. Farxiga helps lower blood sugar by removing excess sugar through urine. It also helps reduce the risk of heart failure and chronic kidney disease complications. On the other hand, Rybelsus lowers blood sugar by increasing insulin release, reducing sugar production in the liver, and slowing digestion. Unlike Farxiga, Rybelsus has a warning for potentially causing thyroid tumors or cancer. Farxiga can cause dehydration and urinary tract infections, while Rybelsus commonly causes nausea, vomiting, and diarrhea. Both medications are brand-name only and are taken orally, but Rybelsus must be taken on an empty stomach first thing in the morning.

Farxiga

(dapagliflozin)

Get free coupons

Rybelsus

(semaglutide)

Get free coupons

Summary for Farxiga

Prescription only

Farxiga, the brand name for dapagliflozin, is used together with a nutritious diet and exercise plan to lower blood sugar levels in people 10 years and older with Type 2 diabetes. It can also help lower the risk of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Farxiga (dapagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's taken by mouth once a day. Some side effects include yeast infections, urinating more often, and weight loss.

Indications for Farxiga

  • Type 2 diabetes (in addition to diet and exercise) in people age 10 and over
  • Lowering the risk of hospitalization for heart failure in adults with Type 2 diabetes and heart disease
  • Lowering the risk of hospitalization and death due to heart problems in people with heart failure
  • Lowering the risk of worsening kidney problems, hospitalization for heart failure, and death due to heart problems in adults with chronic kidney disease (CKD)

Pros and Cons for Farxiga

Pros

  • Taken only once daily
  • Low risk of causing low blood sugar when taken by itself
  • Can take with other diabetes medications

Cons

Common Side Effects for Farxiga

Warnings for Farxiga

  • Ketoacidosis
  • Low fluids in the body (leading to low blood pressure or dehydration)
  • Genital and urinary tract infections
  • Low blood sugar (hypoglycemia) when used with other diabetes medications

Summary for Rybelsus

Prescription only

Rybelsus (semaglutide) is a brand-name GLP-1 agonist that helps lower blood sugar in adults with Type 2 diabetes. It's also FDA approved to help reduce the risk of heart attack, stroke, and heart-related death in people with Type 2 diabetes who are at risk for these events. You take it as a pill once a day, at least 30 minutes before eating, drinking, or taking other medicatons by mouth. It’s used along with diet and exercise, and might also help with weight loss. Common side effects include nausea, stomach pain, and diarrhea.

Indications for Rybelsus

Pros and Cons for Rybelsus

Pros

  • Only needs to be taken once per day
  • First GLP-1 agonist in pill form
  • Helps lower blood sugar and might also support weight loss

Cons

  • Must be taken on an empty stomach
  • Stomach side effects like nausea, diarrhea, and stomach pain are common
  • Can't be used for Type 1 diabetes

Common Side Effects for Rybelsus

  • Nausea (11-20%)
  • Stomach pain (10-11%)
  • Diarrhea (9-10%)
  • Lower appetite (6-9%)
  • Vomiting (6-8%)
  • Constipation (5-6%)

Warnings for Rybelsus

  • Risk of thyroid tumors
  • Inflammation of the pancreas (pancreatitis)
  • Eye problems
  • Low blood sugar (hypoglycemia) when taken with certain diabetes medications
  • Kidney damage
  • Severe stomach side effects
  • Severe allergic reactions
  • Gallbladder problems
  • Lung problems during anesthesia or deep sedation

Prices with our coupons for Farxiga vs. Rybelsus

Price Card Drug Icon
Farxiga30 tablets / 10mg
--
Get free coupons
More Information
Price Card Drug Icon
Rybelsus30 tablets / 3mg
--
Get free coupons
More Information

Compare other Diabetes Type 2 drugs

Brenzavvy vs. FarxigaEntresto vs. FarxigaFarxiga vs. ActosFarxiga vs. AfrezzaFarxiga vs. Glucotrol
Farxiga vs. GlyburideFarxiga vs. InvokanaFarxiga vs. JardianceFarxiga vs. KerendiaFarxiga vs. MetforminFarxiga vs. OzempicFarxiga vs. RybelsusFarxiga vs. WegovyInpefa vs. FarxigaJanuvia vs. FarxigaSteglatro vs. FarxigaActos vs. InvokanaInvokana vs. AfrezzaInvokana vs. GlucovanceInvokana vs. GlyburideInvokana vs. InvokametInvokana vs. LantusInvokana vs. MetaglipInvokana vs. MetforminInvokana vs. OnglyzaInvokana vs. VictozaJanuvia vs. InvokanaJardiance vs. InvokanaPrandin vs. InvokanaSteglatro vs. Jardiance

Browse medications by letter

Show All

Browse prescription and over-the-counter medications from A to Z, compare drug prices, and start saving.