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Diethylpropion vs. Phendimetrazine

Diethylpropion is a medication that's taken by mouth help with obesity and weight loss. It's typically used together with a low-calorie diet and exercise plan. This medication is only meant to be used for a short period of time because it has many potential risks.

• Weight management when diet and exercise alone aren't enough in people with obesity

• Nausea
• Vomiting
• Diarrhea
• Upset stomach
• Constipation
• Dry mouth
• Headache
• Nervousness
• Jitteriness
• Racing heart
• Trouble falling asleep
• Changes in sex drive

• High blood pressure affecting the heart and lungs
• Heart valve problems
• Potential for misuse and dependence

Phendimetrazine, formerly known as brand-name medication Bontril, is a prescription sympathomimetic medication typically used in combination with diet and exercise. It works as an appetite suppressant in the brain to help adults with weight loss. It's available as an immediate-release tablet taken by mouth two to three times per day, and an extended-release capsule taken once per day. Side effects include restlessness, headache, and high blood pressure.

Short-term treatment for weight management in adults with a body mass index (BMI) of:

• 30 kg/m2 or greater; or
• 27 kg/m2 or greater with other risk factors (e.g., high blood pressure, high blood sugar, high cholesterol)

• Fast heartbeat
• High blood pressure
• Restlessness
• Trouble sleeping
• Nervousness
• Shakiness
• Sweating

• Not safe with other weight loss medications
• Lower response to the medication over time
• Risk of misuse and dependence
• High blood pressure in the lungs (pulmonary hypertension)
• Heart valve problem
• Risk of high blood pressure
• Risk of low blood sugar in people with diabetes