Key takeaways
Cymbalta (duloxetine) and Pristiq (desvenlafaxine) are both SNRIs (serotonin and norepinephrine reuptake inhibitors) used to treat depression. However, Cymbalta is also approved for treating anxiety, diabetic neuropathy, fibromyalgia, and long-term pain. Both medications are typically taken once daily, but Cymbalta can be taken twice daily, depending on the condition. Both medications can cause side effects like nausea, dizziness, and dry mouth, but Cymbalta has a higher risk of liver damage and is not recommended for people who drink heavily. Pristiq, on the other hand, can raise blood pressure and is not suitable for those with uncontrolled high blood pressure or heart problems. Both medications require a gradual dose reduction to avoid withdrawal symptoms if you need to stop taking them. Additionally, lower-cost generics are available for both medications.
