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Anoro Ellipta vs. Stiolto Respimat

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Anoro Ellipta (umeclidinium/vilanterol) and Stiolto Respimat (tiotropium/olodaterol) are both inhalers used to manage chronic obstructive pulmonary disease (COPD). Anoro Ellipta combines a long-acting muscarinic antagonist (LAMA) and a long-acting beta-agonist (LABA) and is taken once daily. Stiolto Respimat also combines a LAMA and a LABA but requires two puffs once daily. Anoro Ellipta does not need to be cleaned or primed before use. It has a 6-week expiration once opened. Stiolto Respimat needs to be primed before first use and cleaned weekly. It should be discarder 3 months after first use. Anoro Ellipta contains milk protein, which can cause severe allergies in some people, whereas Stiolto Respimat does not. Both medications are brand-name only and can be expensive, but they do not contain steroids, so you don't need to rinse your mouth after using them.

Anoro Ellipta

(umeclidinium / vilanterol)

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Stiolto Respimat

(tiotropium / olodaterol)

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Summary for Anoro Ellipta

Prescription only

Anoro Ellipta is a steroid-free inhaler that contains umeclidinium (a long-acting muscarinic antagonist, or LAMA) and vilanterol (a long-acting beta agonist, or LABA). It's FDA-approved for maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. This Ellipta inhaler is inhaled through the mouth once per day. Side effects aren't common, but some people have reported sore throat and diarrhea.

Indications for Anoro Ellipta

Pros and Cons for Anoro Ellipta

Pros

  • Combination of two bronchodilators within a single inhaler
  • Inhaled once per day
  • No need to rinse your mouth after a dose since it doesn't contain a steroid

Cons

  • Doesn't replace your rescue inhaler for sudden trouble breathing
  • Can't use if you're severely allergic to milk proteins because it contains lactose
  • Might not be a good choice for people who've trouble urinating

Common Side Effects for Anoro Ellipta

  • Sore throat (2%)
  • Diarrhea (2%)

Warnings for Anoro Ellipta

  • Not for COPD flare ups or worsening breathing
  • Narrowing of your airways (bronchospasm)
  • Serious allergic reactions
  • Worsening narrow-angle glaucoma
  • Trouble urinating
  • Heart problems
  • Low potassium level in the blood

Summary for Stiolto Respimat

Prescription only

Stiolto Respimat is a combination inhaler containing two bronchodilators: tiotropium (a long-acting muscarinic antagonist, or LAMA) and olodaterol (a long-acting beta agonist, or LABA). It's used to treat chronic obstructive pulmonary disease (COPD) in adults. Stiolto Respimat (tiotropium / olodaterol) is taken once per day as 2 inhalations through the mouth. Possible side effects aren't common but can include upper respiratory tract infections and cough.

Indications for Stiolto Respimat

  • Maintenance treatment of COPD

Pros and Cons for Stiolto Respimat

Pros

  • Only taken once per day, typically 2 puffs per dose
  • Produces a slow and fine mist that makes it easier to breathe in
  • No need to rinse your mouth after use since it doesn't contain a steroid

Cons

  • Brand-name medication only
  • Doesn't replace your rescue inhaler for sudden trouble breathing
  • Might worsen certain medical conditions, such as trouble urinating

Common Side Effects for Stiolto Respimat

  • Nose and throat infection (12%)
  • Cough (4%)
  • Back pain (4%)

Warnings for Stiolto Respimat

  • Not for use during worsening COPD symptoms
  • Don't use Stiolto Respimat with LABAs
  • Narrowing of your airways (bronchospasm)
  • Severe allergic reaction
  • Heart problems
  • Eye problems
  • Trouble urinating
  • Low potassium in the blood

Prices with our coupons for Anoro Ellipta vs. Stiolto Respimat

Price Card Drug Icon
Umeclidinium/Vilanterol Ellipta1 inhaler / 60 blisters of 62.5mcg/25mcg
$273.88$552.93
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Stiolto Respimat1 respimat inhaler / 60 inhalations of 2.5mcg/2.5mcg
$478.15$612.56
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