Key takeaways
Aklief (trifarotene) and tretinoin (Retin-A) are both retinoids, which are forms of vitamin A. They are used to treat acne. Aklief (trifarotene) is a topical cream used to treat acne in people aged 9 years and older,, while tretinoin (Retin-A) is an topical medication used to treat acne in adults and children 12 years and older. Both medications are applied once daily. Aklief is only available as a brand-name medication, while tretinoin (Retin-A) is available in generic form. Common side effects of Aklief include skin irritation and sun sensitivity, while tretinoin ((Retin-A) can cause skin irritation, redness, and peeling. You should not use Aklief with other retinoids like tretinoin (Retin-A) cream to prevent side effects.
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