Key takeaways
Oxymetazoline (Afrin) and fluticasone (Flonase) are both nasal sprays, but they work differently and are used for different purposes. Oxymetazoline is an alpha-1 receptor agonist that provides short-term relief for nasal and sinus congestion by tightening blood vessels in your nose. It works quickly, within minutes, but should not be used for more than 3 days to avoid rebound congestion. On the other hand, fluticasone is a corticosteroid used to treat allergy symptoms like runny nose, sneezing, and itchy eyes by reducing inflammation. Fluticasone needs to be used daily for the best results and can be used for up to 6 months (or 2 months for children) without consulting a healthcare provider. While oxymetazoline is available over-the-counter, fluticasone is available OTC and by prescription, and it can have more serious side effects if used long-term, such as nosebleeds and slowed growth in children. Both medications come in different formulations and strengths, so it's important to follow the specific instructions for each.
