Nonsteroidal anti-inflammatory drug (NSAID) / proton pump inhibitor combinations are used to treat inflammatory conditions, such as rehumatoid arthritis, osteoarthritis, and ankylosing spondylitis, while reduing the risk of stomach ulcers. These medications work by combining an NSAID to reduce pain and inflammation with a proton pump inhibitor to protect your stomach lining from irritation and ulcers. They are available as oral tablets. An example of this combination is naproxen / esomeprazole (Vimovo).