Barbiturate and acetaminophen combinations are used to treat tension different types of headaches and migraines. These medications work by combining a barbiturate, which helps you relax, with acetaminophen, which relieves pain. Some of these medications also include caffeine, which can enhance pain relief. These combinations are available in oral forms, such as tablets and capsules. Examples include butalbital / acetaminophen / caffeine and butalbital/acetaminophen (Allzital, Butapap).