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Pulmicort Respules

budesonide
Used for Asthma

Budesonide (Pulmicort Respules) is a prescription medication used to prevent and treat asthma in children. It's an inhaled steroid, which means it lowers lung inflammation to help your child breathe better. Budesonide (Pulmicort Respules) is used with a nebulizer, which turns the inhalation solution into a mist that your child breathes through their mouth and into the lungs. Common side effects include lung infections, stuffy nose, and cough.

Reviewed by:Last reviewed on July 18, 2023
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What is Budesonide (Pulmicort Respules)?

What is Budesonide (Pulmicort Respules) used for?

  • Prevention and maintenance treatment of asthma in children 1 year to 8 years old

How Budesonide (Pulmicort Respules) works

Budesonide (Pulmicort Respules) is a corticosteroid. It reduces chemicals in your body that cause swelling and inflammation. Inflammation in your lungs can lead to difficulty breathing. By lowering inflammation, budesonide (Pulmicort Respules) makes it easier for you to breathe.

Drug facts

Common BrandsPulmicort Respules
Drug ClassIC
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Side effects of Budesonide (Pulmicort Respules)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Lung infection (fever, shortness of breath; 34-38%)
  • Stuffy nose (7-12%)
  • Coughing (5-8%)
  • Ear infection (ear pain, rubbing or tubbing at an ear; 2-12%)
  • Stomach flu (diarrhea, belly pain; 5%)
  • Viral infection (chills, sore throat, body pain; 3-5%)
  • Thrush (yeast infection in your mouth or throat; 3-4%)

Less Common Side Effects

  • Vomiting
  • Nosebleed
  • Pink eye
  • Rash
  • Feeling tired
  • Appetite loss
  • Muscle pain
  • Feeling restlessness
  • Mood changes
  • Trouble speaking
  • Noisy breathing
  • Dry skin

Budesonide (Pulmicort Respules) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic reaction: swelling, rash, trouble breathing

Source: DailyMed

The following Budesonide (Pulmicort Respules) side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Body aches or pain

chills

congestion

cough

diarrhea

dryness or soreness of the throat

fever

general feeling of discomfort or illness

headache

hoarseness

joint pain

loss of appetite

muscle aches and pains

nausea

pain or tenderness around the eyes and cheekbones

shivering

shortness of breath or troubled breathing

sneezing

sore throat

stuffy or runny nose

sweating

tender, swollen glands in the neck

tightness of the chest or wheezing

trouble with sleeping

trouble with swallowing

unusual tiredness or weakness

voice changes

vomiting

Less common

Bruising

darkening of the skin

depression

dizziness

earache

excessive muscle tone

fainting

fractures

large, flat, blue, or purplish patches in the skin

lower back or side pain

muscle stiffness

muscle tension or tightness

painful or difficult urination

redness or swelling in the ear

skin rash

sore mouth or tongue

white patches in the mouth or on the tongue

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain

Less common

Acid or sour stomach

belching

change in taste or bad, unusual, or unpleasant (after) taste

difficulty with breathing

difficulty with moving

dry mouth

ear congestion

headache, severe and throbbing

heartburn

indigestion

muscle cramping

neck pain

sleeplessness

stomach discomfort, upset, or pain

swollen joints

unable to sleep

unexplained runny nose or sneezing

weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Pros and cons of Budesonide (Pulmicort Respules)

Pros

  • Available as a lower-cost generic medication
  • Typically inhaled once a day
  • Safe for children 1 year to 8 years old
  • Works directly in the lungs to prevent asthma

Cons

  • Not safe for use in asthma attacks
  • Possible bone loss if used long term
  • Can cause thrush in mouth or throat as a side effect
  • Takes 4-6 weeks before the full effects of the medication kicks in
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Pharmacist tips for Budesonide (Pulmicort Respules)

pharmacist
  • After using budesonide (Pulmicort Respules), rinse your child's mouth with water and spit it out right away. This can help lower the chances of developing a fungal infection in their mouth and throat (thrush). If your child develops white patches or a cotton-like feeling in the mouth, let their healthcare provider know. Your child might need to take antifungal medication(s) for this side effect.
  • Budesonide (Pulmicort Respules) isn't used to treat symptoms of an asthma attack. If your child has wheezing, cough, shortness of breath, chest pain or tightness, let their provider know right away. Make sure your child has a rescue inhaler, such as albuterol (Ventolin) in case of an asthma flare-up.
  • Budesonide (Pulmicort Respules) should only be inhaled through a jet nebulizer. Avoid using this medication with an ultrasonic nebulizer.
  • The jet nebulizer turns budesonide (Pulmicort Respules) into a mist that's then inhaled into your child's lungs. Don't swallow this medication or mix it with any other medications in the nebulizer. If you have questions about which type of nebulizer to use, ask your child's pharmacist or provider.
  • If your child was taking oral steroids on a regular basis in the past, make sure they carry a warning card with them if they're switching from oral steroids to budesonide (Pulmicort Respules). The warning card should state that your child might need oral steroids during an asthma attack.
  • Make sure your child gets their routine tests done on time while they’re taking budesonide (Pulmicort Respules). This helps your child's provider make sure this medication is working for them and not causing side effects. Typically the provider will check your child's blood works, breathing, and eye exams.
  • Before starting any new medications, speak with your child's provider first. Some medications can interact with budesonide (Pulmicort Respules) and lead to more side effects.
  • Store budesonide (Pulmicort Respules) in an upright position at room temperature in a place away from direct sunlight or light, as this can potentially damage the medication. You should never refrigerate or freeze this medication. When your child isn't using budesonide (Pulmicort Respules), keep the ampules in the protective aluminum foil. Once you open the foil package, the ampules can be stored and used for up to 2 weeks. If the ampules aren't used within 2 weeks, throw them away as they might not work as well anymore.
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Risks and warnings for Budesonide (Pulmicort Respules)

Budesonide (Pulmicort Respules) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Fungal infection in the mouth (oral thrush)

  • Risk factor: Not rinsing mouth after using budesonide (Pulmicort Respules)

There's a chance of fungal infections, such as thrush in the mouth and throat, while using budesonide (Pulmicort Respules). The risk is higher if your child doesn't rinse their mouth right after using this medication. Symptoms of oral thrush include white patches on the inside of the mouth, mouth redness or soreness, and pain while eating or swallowing. If your child develops thrush in their mouth, let their provider know right away. Your child will need to take an antifungal medication to treat the infection.

Risk of worsening of asthma

  • Risk factor: Using budesonide (Pulmicort Respules) during asthma attacks or severe episodes of asthma

Although rare, budesonide (Pulmicort Respules) can worsen symptoms of asthma by tightening the airways. This medical condition is called paradoxical bronchospasm and can be life-threatening if not treated quickly. If your child feels more wheezing, shortness of breath, or coughing after using budesonide (Pulmicort Respules), stop this medication right away and speak to your child's provider.

In addition, budesonide (Pulmicort Respules) shouldn't be used to treat asthma attacks or any severe episodes of asthma. Your child should only use a rescue inhaler, such as albuterol (ProAir), to treat asthma attacks. If your child's rescue inhaler isn't working well to control their symptoms, let the provider know because your child might need additional medications, such as steroid pills.

Serious allergic reaction

  • Risk factor: History of allergy to medications containing budesonide

In some rare cases, budesonide (Pulmicort Respules) can cause allergic reactions, which can be life-threatening. Don't use this medication if your child has a history of allergy to medications containing budesonide. Watch out for signs and symptoms of allergic reactions, such as wheezing, dizziness, fainting, rash, itching, trouble breathing, and swelling of the tongue or throat. Get medical attention right away if your child has any of these reactions.

Higher risk of infection

  • Risk factors: Active, chronic (long-term), or recurrent infection | Medical conditions that weaken the immune system | Taking other medications that can weaken the immune system

Budesonide (Pulmicort Respules) can lower your child's ability to fight infections. Infections, such as tuberculosis (TB), chickenpox, and measles, can be more serious in people who use budesonide (Pulmicort Respules). If your child has any of the risk factors listed above, discuss with their provider about how they can safely use this medication. Don't use budesonide (Pulmicort Respules) if your child has an active infection or an infection that keeps coming back without speaking with their provider first. Budesonide (Pulmicort Respules) can make these infections worse. Let your child's provider know right away if they have signs or symptoms of an infection, such as fever, cough, white patches in your mouth, or sore throat.

Switching from oral to inhaled steroids

  • Risk factors: Long-term use of oral steroids | Suddenly stopping prednisone 20 mg or equivalent dose of steroid for treatment of asthma | History of asthma

When switching from an oral to an inhaled steroid, your child's provider might closely observe your child for withdrawal symptoms, such as nausea, tiredness, weakness, or muscle and joint pain. This is because switching between different forms of steroids can affect the cortisol levels in your child's body. Cortisol is a steroid hormone that controls blood sugar, blood pressure, and other important functions in your child's body. It also helps the body respond to stressful situations, such as trauma, surgery, and infection. Don't switch between steroids without proper guidance from your child's provider. Let their provider know if your child develops any symptoms, such as tiredness, weakness, loss of energy, nausea, vomiting, or low blood pressure.

If your child has used oral steroids for long periods of time and has asthma, it's important to carry a warning card with you that states that your child might need steroid pills during an asthma attack. In these cases, a rescue inhaler alone might not be enough to treat their asthma attack. So it's important that those taking care of your child are aware of their situation. Your child's provider might also perform tests to monitor your child's lung function and breathing more closely.

Reduced adrenal gland function

  • Risk factors: Using high potency steroids | Using steroids for a long period of time | Using oral steroids | Stressful events (e.g., surgery) | Young children

In very rare cases, using inhaled budesonide (Pulmicort Respules) for a long time can cause a medical condition called adrenal suppression. This happens when your adrenal gland doesn't make enough of steroid hormones for your body, which creates a dependence on steroid medication. If you suddenly stop the medication, it can be dangerous to your body. In adults, symptoms of withdrawal include fever, joint or muscle pain, and low energy. In children, symptoms often include stunted growth, weight gain, and headaches. To prevent adrenal suppression from happening, your child's provider will prescribe the lowest possible dose of budesonide (Pulmicort Respules) that works well for your child for the shortest amount of time. If your child needs to use budesonide (Pulmicort Respules) for a long period of time, their provider might ask them to do some lab work to test how well their adrenal gland works. Let your child's provider know if your child has symptoms of withdrawal. Don't suddenly stop using budesonide (Pulmicort Respules) without talking to their provider first.

Risk of bone loss and poor growth

  • Risk factors: Using budesonide (Pulmicort Respules) long term | Unable to move for a long period of time | Family history of osteoporosis | Poor diet | Using medications that can cause bone loss

People taking budesonide (Pulmicort Respules) for a long time might be at risk of bone loss or poor growth. If your child has any of the risk factors listed above, they might be more likely to experience weaken bones or slowed growth after using budesonide (Pulmicort Respules) long-term. Your child's provider might measure your child's bone density regularly to make sure their bones are healthy. If your child has had bone fractures before, talk to your child's provider about their risk before using this medication.

Eye problems

  • Risk factors: Long-term use of budesonide (Pulmicort Respules) | History of eye problems like glaucoma or cataracts

Using budesonide (Pulmicort Respules) for a long time can raise eye pressure, worsen glaucoma, and cause cataracts (cloudiness in the eyes). Talk to your child's provider right away if they experience blurry vision, eye discomfort, or other changes in their vision after using budesonide (Pulmicort Respules). Your child might need an eye exam.

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Budesonide (Pulmicort Respules) dosage

The average cost for 30 ampules of 0.5mg/2ml of Budesonide (Pulmicort Respules) is $48.30 with a free GoodRx coupon. This is 61.97% off the average retail price of $127.01.
ampuleAmpule
DosageQuantityPrice as low asPrice per unit
0.25mg/2ml30 ampules$55.50$1.85
0.5mg/2ml30 ampules$48.30$1.61
1mg/2ml30 ampules$155.28$5.18

Typical dosage for Budesonide (Pulmicort Respules)

Your child's provider will determine their dose of budesonide (Pulmicort Respules) based on what medications they were taking previously treat asthma.

  • The typical dose for budesonide (Pulmicort Respules) ranges from 0.5 mg to 1 mg daily inhaled by mouth through a nebulizer, all at once or split into 2 divided doses.
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Interactions between Budesonide (Pulmicort Respules) and other drugs

Budesonide (Pulmicort Respules) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Budesonide (Pulmicort Respules). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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How much does Budesonide (Pulmicort Respules) cost?

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Budesonide (Pulmicort Respules) (generic)
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$38.55

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Budesonide (Pulmicort Respules) contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Budesonide (Pulmicort Respules) will not be safe for you to take.

  • Asthma attacks or severe episodes of asthma
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What are alternatives to Budesonide (Pulmicort Respules)?

There are a number of medications that your doctor can prescribe in place of Budesonide (Pulmicort Respules). Compare a few possible alternatives below.
Budesonide (Pulmicort Respules)
Used for:
  • Prevention and maintenance treatment of asthma in children 1 year to 8 years old
$38.55Lowest GoodRx priceView prices
Used for:
  • Maintenance treatment of asthma
$123.68Lowest GoodRx priceView prices
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  • Maintenance treatment of asthma in people age 12 years and older
$146.25Lowest GoodRx priceView prices
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News about Budesonide (Pulmicort Respules)

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Budesonide (Pulmicort Respules) images

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white - Budesonide 0.5mg/2mL Suspension for Inhalation
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white - Budesonide 0.5mg/2mL Suspension for Inhalation
This medicine is White Ampule.white - Budesonide 0.5mg/2mL Suspension for Inhalation
This medicine is Colorless Ampule.
This medicine is Colorless Ampule.

References

Best studies we found

AstraZeneca Pharmaceuticals LP. (2019). PULMICORT RESPULES- budesonide suspension [package insert]. DailyMed.

Centers for Disease Control and Prevention. (2021). Candida infections of the mouth, throat, and esophagus.

Centers for Disease Control and Prevention. (2022). About chickenpox.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.