Esomeprazole (Nexium) and omeprazole (Prilosec) and are two of the most popular prescriptions for GERD (gastroesophageal reflux or acid reflux), but which one is better? Many insurance plans don’t cover esomeprazole and instead want patients to use omeprazole. But is esomeprazole actually worth fighting for?
This is what researchers found:
- Compared to omeprazole 20 mg, esomeprazole 40 mg provides greater acid control in patients with GERD and keeps stomach pH at higher than 4 for a longer period of time (higher pH = less acidity = less pain).
- What about esomeprazole 40 mg vs. omeprazole 40 mg? Esomeprazole 40 mg provides more effective acid control than omeprazole 40 mg, twice the standard dose of omeprazole or one over-the-counter tablet of omeprazole 20 mg.
- What about esomeprazole 20 mg vs. omeprazole 20 mg? In a study on healthy men, a single pill of esomeprazole 20 mg (Nexium 24 hr) raised intragastric pH faster than omeprazole 20 mg (Prilosec OTC). So, Nexium 24 hr appears to be more effective than Prilosec OTC.
- Esomeprazole 40 mg has also been found to be the fastest-acting proton pump inhibitor drug, followed by lansoprazole (Prevacid) and rabeprazole (Aciphex). Proton pump inhibitors prevent your stomach from becoming more acidic.
To Sum It Up
There appears to be convincing evidence that esomeprazole works better to lower acidity in the gut and improve symptoms of GERD compared to omeprazole. If your insurance plan is no longer covering esomeprazole, it may be worth your physician trying a prior authorization or searching out a good cash-pay price for your prescription esomeprazole 40 mg tablets.
We've sent a link to download the GoodRx mobile app to your phone.
We were unable to send a link to your phone.