Esomeprazole (Nexium) vs. Omeprazole (Prilosec): Which is Better for Acid Reflux?

Dr. Sharon Orrange
Dr. Orrange is an Associate Professor of Clinical Medicine in the Division of Geriatric, Hospitalist and General Internal Medicine at the Keck School of Medicine of USC.
Posted on

Esomeprazole (Nexium) and omeprazole (Prilosec) and are two of the most popular prescriptions for GERD (gastroesophageal reflux or acid reflux), but which one is better? Many insurance plans don’t cover esomeprazole and instead want patients to use omeprazole. But is esomeprazole actually worth fighting for?

Turns out, many clinical trials over the years have asked this question: is esomeprazole (Nexium) better for acid reflux symptoms compared to omeprazole (Prilosec)?

This is what researchers found:

To Sum It Up

There appears to be convincing evidence that esomeprazole works better to lower acidity in the gut and improve symptoms of GERD compared to omeprazole. If your insurance plan is no longer covering esomeprazole, it may be worth your physician trying a prior authorization or searching out a good cash-pay price for your prescription esomeprazole 40 mg tablets.

Dr O.

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