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Savaysa

edoxaban
Used for Atrial Fibrillation, Deep Vein Thrombosis, Pulmonary Embolism, Stroke Risk Reduction
Used for Atrial Fibrillation, Deep Vein Thrombosis, Pulmonary Embolism, Stroke Risk Reduction

Savaysa, the brand name for edoxaban, is an anticoagulant (blood thinner). It’s used to help prevent blood clots and strokes in certain people with atrial fibrillation. This medication can also treat blood clots. The dose is typically one 60 mg tablet by mouth once daily, but it might be lower if you have kidney problems. Since it’s a blood thinner medication, Savaysa (edoxaban) can raise your chance of bleeding as a side effect. As of early 2025, there's no FDA-approved generic version available yet.

Reviewed by:
reviewer
Hope Chang, PharmD, AAHIVP
reviewer
Mae-Mae Han, PharmD Candidate
reviewer
Cydnee Ng, PharmD
Last reviewed on April 17, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Savaysa (edoxaban)?

What is Savaysa (edoxaban) used for?

How Savaysa (edoxaban) works

Savaysa (edoxaban) is an anticoagulant (blood thinner). It works by stopping a protein called factor Xa. Factor Xa helps your body make clots.

By blocking factor Xa, Savaysa (edoxaban) helps prevent blood clots from forming. This lowers the risk of having blood clots that can lead to other problems like a stroke.

When it’s used for treating a blood clot, Savaysa (edoxaban) helps make sure the clot doesn’t get bigger.

When does Savaysa (edoxaban) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsSavaysa
Drug ClassAnticoagulant
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Savaysa (edoxaban)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Any type of bleeding

Other Side Effects

  • Rash
  • Change in liver tests
  • Low red blood cell count (anemia)

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious bleeding or large loss of blood: frequent nosebleeds, severe weakness, confusion, coughing up blood, severe vomiting, bloody urine, dark and tarry stool
  • Problems from bleeding around the spinal cord after spinal procedures: numbness, weakness, tingling or burning feeling in your back or legs, can’t control your bladder or bowel movements
When do Savaysa (edoxaban) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Risk of easy bleeding or bruising
Risk of serious bleeding
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
  • Bleeding in the brain—severe headache, stiff neck, confusion, dizziness, change in vision, numbness or weakness of the face, arm, or leg, trouble speaking, trouble walking, vomiting
  • Heavy periods
pros-and-cons

Pros and cons of Savaysa (edoxaban)

thumbs-up

Pros

Oral medication that's only taken once a day

Can take with or without food and doesn't interact with any specific foods

Doesn't require frequent blood tests to check how well it’s working and how safe it is

thumbs-down

Cons

Not for people with nonvalvular atrial fibrillation (NVAF) whose kidneys work too well

Not recommended if you have artificial heart valves or certain problems with your heart valves

Doesn't have an antidote (an option to reverse serious bleeding)

pharmacist-tips

Pharmacist tips for Savaysa (edoxaban)

pharmacist

  • Follow your prescriber or pharmacist’s directions when switching between blood thinners. For example, you might switch from warfarin (Coumadin) to Savaysa (edoxaban), or from Savaysa (edoxaban) to another blood thinner. They’ll tell you when to stop the old blood thinner and when to start the new one. This makes sure there aren’t any gaps in your treatment to lower your risk for blood clots or a stroke.

    • Take Savaysa (edoxaban) with or without food at the same time every day. Taking the medication the same way and time every day can help you remember to take it since it becomes a part of your daily routine.

      • To make sure you don’t get a clot, don’t stop taking Savaysa (edoxaban) without instructions from your prescriber. And always call the pharmacy for refills ahead of time so that you don’t run out of medication at home.

        • Savaysa (edoxaban) can cause easy bleeding or bruising. Although not common, also be sure to watch out for signs of more serious bleeding. This can include frequent nosebleeds, confusion, coughing up blood, severe vomiting, or having dark, tarry stool. If you’re worried about any bleeding or think it’s serious, get immediate medical help.

          • If you miss your dose of Savaysa (edoxaban), take it as soon as you remember as long as it's the same day. If it's the next day, skip the missed dose and wait to take the medication when you usually do. Never double up on doses because it raises your risk of bleeding.

            • Make sure all your healthcare professionals (HCPs), dentists, and surgeons know you're taking Savaysa (edoxaban). This medication can make it more likely for you to bleed during a procedure. So your HCP might tell you to stop taking Savaysa (edoxaban) for a short time before the procedure. Then, they’ll give you instructions on how to start your blood thinner again. This can include a transition period with an injectable blood thinner like enoxaparin (Lovenox).

              • Talk to your prescriber if you’re taking Savaysa (edoxaban) and become pregnant or plan to become pregnant. There’s not enough information to know if this medication is safe during pregnancy. Your prescriber will probably suggest an injectable anticoagulant, like enoxaparin (Lovenox), that’s safer to use while pregnant.

                • It’s not recommended to breastfeed while taking Savaysa (edoxaban). There haven’t been any studies about the medication in people who are breastfeeding or the effects it could have on an infant. But there’s a potential for serious harm to the infant, like serious bleeding. Talk to your prescriber about the best options for you.

                  More on Savaysa (edoxaban) tips

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                  faqs

                  Frequently asked questions about Savaysa (edoxaban)

                  Is Savaysa (edoxaban) a blood thinner?
                  Yes, Savaysa (edoxaban) is a type of blood thinner. More specifically, it’s called a direct oral anticoagulant (DOAC). Savaysa (edoxaban) works by blocking a clotting factor called factor Xa, which is a protein that helps your body make clots. Blocking this clotting factor stops your blood from clotting and "thins" your blood.
                  Can Savaysa (edoxaban) be crushed?
                  Yes. People who can’t swallow the Savaysa (edoxaban) tablet whole can crush it. Mix the crushed tablet with 2 to 3 ounces of water or applesauce. Then, swallow the mixture right away. If you use a gastric tube (a type of feeding tube), mix the crushed tablet with 2 to 3 ounces of water and put the mixture into the tube right away. Don't let the mixture sit out for a long time.
                  What medications shouldn't be taken with Savaysa (edoxaban)?
                  Avoid taking Savaysa (edoxaban) with rifampin, as it can lessen the amount of Savaysa (edoxaban) in your system. This increases your risk for a clot. Talk to your prescribers if you need to take certain medications that can raise your risk of bleeding. These include other blood thinners, antiplatelets (including aspirin), and certain antidepressants (SSRIs and SNRIs). Savaysa (edoxaban) itself has a risk of bleeding. So taking these medications together with Savaysa (edoxaban) can put you at even higher risk. Give your prescriber and pharmacist a full list of the medications you take. They can check for dangerous drug interactions and make sure you’re safe.
                  What foods do you need to avoid when taking Savaysa (edoxaban)?
                  There aren't any particular foods you need to avoid when taking Savaysa (edoxaban). Food doesn't affect the levels of Savaysa (edoxaban) in your system. But you should generally avoid drinking alcohol while taking blood thinners because it can raise your risk of bleeding.
                  How long does Savaysa (edoxaban) take to work?
                  Savaysa (edoxaban) starts to work within a couple of hours to thin your blood. This helps prevent clots from forming or getting bigger. Continue taking the medication as your prescriber told you to to keep clots from forming.
                  When do you stop taking Savaysa (edoxaban) before surgery?
                  Usually, your healthcare professional (HCP) will ask you to stop taking Savaysa (edoxaban) at least 24 hours before a major surgery because of the risk of bleeding. But you should always check with the medical professional performing your procedure. They might want you to stop taking this medication a few days before. Follow your HCP's directions before surgery, and never stop taking the medication without speaking to your HCP first.
                  Does Savaysa (edoxaban) cause hair loss?
                  Hair loss isn't a common side effect of Savaysa (edoxaban). If you experience hair loss while taking this medication, speak to your prescriber so they can help identify the cause.
                  What's the difference between Eliquis and Savaysa?
                  Savaysa (edoxaban) and Eliquis (apixaban) are both blood thinners that can help prevent and treat blood clots. They both come as tablets that are taken by mouth. But Savaysa is taken once daily, whereas Eliquis is taken twice daily. For people who have trouble swallowing pills whole, both medications can be crushed up and mixed with water. It’s best to take the mixtures immediately. But you can store the Eliquis mixture for up to 4 hours if needed. Ask your prescriber to compare the blood thinners and see which one is right for you.
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                  warings-icon

                  What are the risks and warnings for Savaysa (edoxaban)?

                  Savaysa (edoxaban) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  Less effective for people with atrial fibrillation whose kidneys work too well

                  • Risk factors: Excellent kidney function (filtration rate that’s greater than 95 mL/min) | Younger age

                    People with nonvalvular atrial fibrillation and a creatinine clearance greater than 95 mL/min shouldn’t take Savaysa (edoxaban). In studies, these people had a higher risk of having a stroke while taking Savaysa (edoxaban) than those who took warfarin (Coumadin).

                    Creatinine clearance is a measure of kidney function. It describes how quickly your kidneys filter things out of your blood. This includes medications like Savaysa (edoxaban). The higher the creatinine clearance, the faster your kidneys filter things out. When the body gets rid of Savaysa (edoxaban) too quickly, the medication might not work as well. This can raise the risk of blood clots.

                    Your prescriber will check your kidney function before you start Savaysa (edoxaban). They might also check whenever they think it’s necessary during treatment. Be sure to get any blood work done as instructed to make sure Savaysa (edoxaban) is safe for you.

                    risk-warning

                    Higher risk of blood clots or stroke when you stop the medication too soon

                    Don't stop taking Savaysa (edoxaban) before your prescriber tells you to. If you do, you could be at a higher risk for a stroke or heart attack, especially if you have nonvalvular atrial fibrillation. Talk to your prescriber first if you want to stop taking this medication or switch to a different blood thinner.

                    risk-warning

                    Bleeding risk

                    • Risk factors: Taking nonsteroidal anti-inflammatory drugs (NSAIDs) or other medications that increase risk of bleeding | People at higher risk of bleeding | People with kidney or liver problems

                      Savaysa (edoxaban) can raise the risk of bleeding. Sometimes, bleeding can be serious or life-threatening. The risk is higher if you take Savaysa (edoxaban) with other medications that also make bleeding more likely. Signs of serious bleeding can include intense pain, feeling very weak, fast breathing, bloody vomit, or bloody stool. If you have any of these signs, get medical help right away.

                      It's very important that all your healthcare professionals and the emergency medical team know you're taking Savaysa (edoxaban). You might also want to wear a medical alert bracelet that says you take this medication. This helps medical staff know how to respond in an emergency even if you can’t communicate with them. There are ways to treat bleeding caused by Savaysa (edoxaban) in an emergency. But it doesn’t have an antidote like some other blood thinners do.

                      risk-warning

                      Risk of bleeding around the spinal cord after spinal procedures

                      • Risk factors: Spinal puncture (spinal tap) | Getting anesthesia in or around the spine (spinal or epidural anesthesia) | Using a spinal catheter after surgery | History of spinal surgery | Taking nonsteroidal anti-inflammatory drugs (NSAIDs) or other blood thinners

                        Tell your care team that you’re taking a blood thinner like Savaysa (edoxaban) before you have back surgery or any kind of spinal procedure. They’ll consider the risks and benefits for you. Blood thinners can make it more likely for you to bleed around your spinal cord during a spinal tap or epidural. This bleeding could cause paralysis. Call your prescriber right away if you feel pain, tingling, burning, numbness, weakness, or have trouble urinating. These could be signs of a spinal cord problem.

                        risk-warning

                        Higher risk of clotting in people with triple-positive antiphospholipid syndrome

                        Savaysa (edoxaban) isn’t recommended for people with triple-positive antiphospholipid syndrome (APS), an autoimmune condition that can make it more likely to form clots. People with APS might be more likely to have another clot when taking blood thinners like Savaysa (edoxaban) compared to those taking warfarin (Coumadin).

                        dosage

                        Savaysa (edoxaban) dosage forms

                        The average cost for 30 tablets of 60mg of Savaysa (edoxaban) is $423.43 with a free GoodRx coupon. This is 22.24% off the average retail price of $544.52.
                        tablet
                        Tablet
                        DosageQuantityPrice as low asPrice per unit
                        15mg30 tablets$458.32$15.28
                        30mg30 tablets$423.00$14.10
                        60mg30 tablets$423.43$14.11

                        Typical dosing for Savaysa (edoxaban)

                        The typical dose is one 60 mg tablet by mouth once a day.

                        Some people might need to take a lower dose (one 30 mg tablet once a day). This includes people who have kidney problems. For treating blood clots, it also includes people who weigh 132 lbs or less and people who take certain medications.

                        drug-cost

                        How much does Savaysa (edoxaban) cost?

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                        contraindications-icon

                        Savaysa (edoxaban) contraindications

                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Savaysa (edoxaban) will not be safe for you to take.

                        • Active bleeding

                        alternatives

                        What are alternatives to Savaysa (edoxaban)?

                        There are a number of medications that your doctor can prescribe in place of Savaysa (edoxaban). Compare a few possible alternatives below.
                        Savaysa (edoxaban)
                        Used for:
                        $423.00 Lowest GoodRx priceView Prices
                        Warfarin (Coumadin)
                        Used for:

                        • Prevention and treatment blood clots in the veins

                        • Prevention and treatment blood clots linked to atrial fibrillation (AFib) or heart valve replacement

                        • Prevention of more blood clots and to lower risk of death after a heart attack

                        $4.00 Lowest GoodRx priceView Prices
                        Xarelto (rivaroxaban)
                        Used for:
                        $75.18 Lowest GoodRx priceView Prices
                        latest news

                        What is the latest news about Savaysa (edoxaban)?

                        Blood thinners like Eliquis and Xarelto are the preferred drug of choice for treating atrial fibrillation (AFib). Learn about how they work, plus other alternatives, here.

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                        You can exercise on blood thinners. In fact, it’s often encouraged. But it’s important to take some precautions. Learn more with GoodRx.

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                        Blood banks across the country are constantly calling for people to donate blood to patients in need. Find out if your medication might disqualify you here.

                        What Medications Disqualify You From Donating Blood, Plasma, or Platelets?

                        Blood banks across the country are constantly calling for people to donate blood to patients in need. Find out if your medication might disqualify you here.
                        Anticoagulants help treat and prevent blood clots. Learn about the most common blood thinner medications and how to decide which is right for you.

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                        Warfarin has been the go-to drug for decades to help people who need a blood thinner. Recently a new class of drugs arrived, promising better results - at a much higher price. Here’s a look at how they took over the market in just a few years.

                        What’s Better than Warfarin? A Case Study in New Drugs Coming to Market

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                        Savaysa (edoxaban) images

                        Yellow Round Dsc L60 - Savaysa 60mg Tablet
                        This medicine is Yellow, Round Tablet Imprinted With "Dsc L60".Yellow Round Dsc L60 - Savaysa 60mg Tablet

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                        References

                        Best studies we found

                        American Heart Association. (2024). Problem: Mitral valve stenosis.

                        American Heart Association. (2024). Types of replacement heart valves.

                        Aphena Pharma Solutions - Tennessee, LLC. (2021). Eliquis- apixaban tablet, film coated [package insert]. DailyMed.

                        View All References (13)

                        Daiichi Sankyo Inc. (2024). Savaysa- edoxaban tosylate tablet, film coated [package insert]. DailyMed.

                        Douketis, J. D., et al. (2015). Perioperative bridging anticoagulation in patients with atrial fibrillation. The New England Journal of Medicine.

                        DrugBank. (n.d.). P-glycoprotein inhibitors.

                        March of Dimes. (2024). Blood clots and pregnancy.

                        MedlinePlus. (2022). Antiphospholipid syndrome.

                        MedlinePlus. (2023). Blood clots.

                        MedlinePlus. (2023). Cerebrospinal fluid (CSF) collection.

                        MedlinePlus. (2023). Creatinine clearance test.

                        MedlinePlus. (2023). Spinal and epidural anesthesia.

                        MedlinePlus. (2024). Blood thinners.

                        MedlinePlus. (2024). Feeding tube insertion - gastrostomy.

                        National Bleeding Disorders Foundation. (n.d.). The clotting cascade.

                        National Heart, Lung, and Blood Institute. (2022). What is anemia?

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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