provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Prempro Coupon - Prempro 28 tablets of 0.3mg/1.5mg package

Prempro

conjugated estrogens / medroxyprogesterone
Used for Osteoporosis, Menopause
Used for Osteoporosis, Menopause

Prempro is a combination estrogen/progestin medication that relieves menopausal symptoms like vaginal dryness and hot flashes. It's also used for preventing osteoporosis after menopause. This hormone replacement therapy is an option for people with a uterus. The medication is brand only since there is no generic available. Follow your prescriber's instructions for the correct dose. Prempro is taken by mouth once a day with the same dose each day. Premphase is also taken daily but contains two types of tablets: one with estrogen and one with conjugated estrogens plus medroxyprogesterone, taken on different days. Common side effects include breast pain, headaches, and menstrual cramps.

Reviewed by:
reviewer
Allison Gourley, PharmD
reviewer
Kristianne Hannemann, PharmD
Last reviewed on October 21, 2021
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Prempro?

What is Prempro used for?

How Prempro works

Prempro is a combination of two medications:

  • Conjugated estrogens is a mixture of estrogens. It replaces the estrogen your body loses during menopause. It relieves symptoms of menopause like hot flashes and vaginal dryness and also strengthens bones.

  • Medroxyprogesterone is a progestin. It acts like progesterone and helps balance the effect of estrogen on the growth of your uterine lining.

Are you looking for information on Premarin (conjugated estrogens) oral tablets or Premarin (conjugated estrogens) vaginal cream instead?

Drug Facts

Common BrandsPrempro, Premphase
Drug ClassEstrogen replacement / Progestin
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$320.76(save 69.19%)
Manufacturer exclusive discount
$98.84
See prices
basics-icon

What are the side effects of Prempro?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Breast pain (up to 36%)
  • Headaches (up to 19%)
  • Stomach pain (up to 17%)
  • Menstrual cramps (up to 13%)
  • Gas (up to 8%)
  • Nausea (up to 8%)
  • Depression (up to 8%)
  • More vaginal discharge than usual (up to 8%)

Other Side Effects

  • Back pain
  • Weakness
  • Dizziness
  • Migraines
  • Itching
  • Breast growth
  • Vaginal pain
  • Weight gain

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe allergic reactions: swelling of the tongue or throat, trouble breathing, skin rash or hives
  • Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw
  • Stroke: sudden trouble talking or walking, numbness on one side of your body or face, severe headache, dizziness, confusion
  • Blood clot: chest pain, shortness of breath, dizziness, fast heart rate, swelling, pain, or redness in the arms or legs
  • Cancer: lumps, pain, swelling, or changes in the breasts; swollen lymph nodes, unusual or heavy vaginal bleeding, bloating, extreme tiredness, stomach-area pain
When do Prempro possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Breast tenderness
Headache

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the urine

blurred vision

chest pain

clear or bloody discharge from the nipple

cough or hoarseness

dimpling of the breast skin

dizziness

fast, irregular, pounding, or racing heartbeat or pulse

feeling faint, dizzy, or lightheaded

feeling of warmth or heat

fever or chills

flushing or redness of the skin, especially on the face and neck

headache

inverted nipple

lower back or side pain

lump in the breast or under the arm

nervousness

pain during sexual intercourse

painful or difficult urination

persistent crusting or scaling of the nipple

pounding in the ears

redness or swelling of the breast

severe cramping of the uterus

sore on the skin of the breast that does not heal

sweating

thick, white vaginal discharge with no odor or with a mild odor

tingling of the hands or feet

unusual weight gain or loss

vaginal bleeding that is unusual and heavy

vaginal or genital itching

vaginal yeast infection

Incidence not known

Absent, missed, or irregular menstrual periods

acid or sour stomach

anxiety

backache

breast pain or tenderness

confusion

constipation

darkened urine

decreased vision or other changes in vision

difficulty with speaking

double vision

fainting

heartburn

inability to move the arms, legs, or facial muscles

inability to speak

indigestion

loss of appetite

nausea

pain or discomfort in the arms, jaw, back, or neck

pain or feeling of pressure in the pelvis

pain, redness, or swelling in the arm or leg

painful or tender cysts in the breasts

pains in the stomach, side, or abdomen, possibly radiating to the back

slow speech

sudden shortness of breath or troubled breathing

unexpected or excess milk flow from the breasts

vomiting

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain

depression

excess gas in the stomach or intestines

lack or loss of strength

Less common

Blemishes on the skin

body aches or pain

congestion

depersonalization

diarrhea

difficulty with moving

dry skin

dryness of the vagina

dysphoria

euphoria

excessive muscle tone

feeling paranoid

flu-like symptoms

fullness or swelling of the breasts

hair loss or thinning of the hair

headache, severe and throbbing

leg cramps

loss of bladder control

menstrual periods that are longer or heavier

muscle pain or stiffness

pain in the joints

pain or tenderness around the eyes and cheekbones

pimples or acne

quick to react or overreact emotionally

rapidly changing moods

rash

sleeplessness

sore mouth or tongue

stuffy or runny nose

tender, swollen glands in the neck

tightness of the chest or wheezing

trouble with sleeping

trouble with swallowing

vaginal discharge that is clear or white

voice changes

white patches in the mouth or on the tongue

Incidence not known

Changes in appetite

hives or welts

inability to have or keep an erection

increased hair growth, especially on the face

increased interest in sexual intercourse

irritability

loss in sexual ability, desire, drive, or performance

loss of scalp hair

pain in the ankles or knees

painful, red lumps under the skin, mostly on the legs

patchy brown or dark brown discoloration of the skin

redness of the skin

weight changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Prempro

thumbs-up

Pros

Only need to take once a day by mouth

Relieves multiple menopausal symptoms

Includes a progestin which helps protect your uterus

Lowers your risk of fractures by keeping your bones healthy

thumbs-down

Cons

Raises your risk of certain cancers, blood clots, and strokes

Has more possible side effects than similar alternatives

Not safe if you have liver problems

Can't be used if you have a history of breast cancer

pharmacist-tips

Pharmacist tips for Prempro

pharmacist

  • You can take Prempro with or without food. If you feel nauseous, try taking it with something to eat. For best results, take this medication at the same time each day.

    • A similar version called Premphase contains two different types of tablets. Be sure to take them in the order shown on the pack. If you’re unsure how to take it, ask your pharmacist for help.

      • If you miss a dose of Prempro, take it as soon as you remember. But if it’s almost time for your next dose, skip the missed one and stick to your regular schedule. Don’t take two doses at once since that could raise your risk for side effects.

        • Most people begin to feel relief from menopausal symptoms within a few weeks of starting Prempro. Talk to your prescriber if you've been using this medication for a month and still don't feel any better.

          • Check in with your prescriber regularly (every 3 to 6 months) to decide if you should keep taking Prempro. Like other estrogen replacement medications, Prempro can raise your risk of serious problems like breast cancer, heart attacks, and blood clots if taken for a long time. It's best to use this medication for the shortest time necessary.

            • Tell your prescriber right away if you have unusual vaginal bleeding, breast lumps, changes in vision, or severe headaches after starting Prempro. These aren't common side effects and could be a sign of more serious problems.

              faqs

              Frequently asked questions about Prempro

              Can I take Prempro every other day?
              It’s important to take Prempro exactly as prescribed. Taking it every other day instead of every day can affect how well the medication works. If you’re thinking about changing how you take Prempro, talk to your prescriber first to make sure it’s safe and right for you.
              Does Prempro cause weight gain?
              Possibly. In clinical studies, about 3% of people taking Prempro experienced weight gain. Keep in mind that weight changes are a common symptom of menopause. Staying active with a regular exercise routine, like walking or running, can help reduce this risk and also lower your chances of bone loss (osteoporosis).
              Should I take Prempro in the morning or at night?
              You can take Prempro in the morning or at night, but it's important to take it at the same time every day (e.g., always in the morning or always in the evening). Since Prempro might cause sleep problems like insomnia, you could try taking a dose in the morning if it keeps you awake at night.
              Is Prempro low dose?
              Prempro contains 0.625 mg of conjugated estrogens. Generally, 0.5 mg of estrogen daily is considered "low dose" and 1 mg is a "standard dose". Talk to your prescriber if you have questions about the right amount of estrogen for you.
              How long does it take for Prempro to work?
              Most people begin to feel relief from menopausal symptoms within a few weeks of starting Prempro. If you don’t notice any improvement after a month, talk to your prescriber.
              What's the difference between Prempro and Premphase?
              A pack of Prempro contains 28 tablets that are all the same. Each tablet contains both conjugated estrogens and medroxyprogesterone. On the other hand, Premphase has two different types of tablets: the first 14 tablets contain only conjugated estrogens, while tablets for days 15 to 28 include both conjugated estrogens and medroxyprogesterone. Speak with your prescriber to determine which medication is best for you.
              Are Premarin and Prempro the same?
              No. Premarin contains only conjugated estrogens, while Prempro contains both conjugated estrogens and medroxyprogesterone. Prempro is typically only prescribed for people with a uterus, whereas Premarin can also be given to people without a uterus and is used to treat more conditions, including certain advanced stages of breast cancer and prostate cancer.
              Does Prempro cause hair loss?
              Hair loss from taking Prempro is rare, with less than 2% of people in clinical studies reporting it. Your prescriber will likely recommend using this medication for the shortest amount of time to manage your symptoms. If hair loss continues after stopping the medication, speak with your healthcare team about other possible causes.
              GoodRxEducationalIcon

              How to save using GoodRx

              Compare Prices
              1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
              Select your free coupon
              2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
              Show coupon to your pharmacist
              3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
              Get free couponLearn more
              warings-icon

              What are the risks and warnings for Prempro?

              Prempro can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Risk of blood clot

              • Risk factors: People ages 50 years and older| High blood pressure | People identified as obese | High cholesterol | Diabetes | History of smoking cigarettes | Recent surgery or bedrest

                Prempro can raise the risk of serious blood clots because it contains estrogens. Higher estrogen levels can raise blood proteins that promote clot formation. These clots can form anywhere in the body and might be life-threatening. Get medical attention right away if you have any signs or symptoms of a blood clot:

                • Brain (e.g., stroke): weakness or numbness in your arms, legs, or face on one side of the body, trouble speaking, blurry vision, dizziness, loss of balance, trouble walking, or confusion

                  • Eyes (e.g., retinal thrombosis): trouble seeing, bulging eye, double vision

                    • Heart (e.g., heart attack): chest pain, sweating, nausea, or dizziness

                      • Lungs (e.g., pulmonary embolism or PE): trouble breathing, chest pain, or cough

                        • Legs (e.g., deep vein thrombosis or DVT): cramps, swelling, pain, or muscle tightness

                          Your risk of blood clots is higher if you're older, smoke cigarettes, or have certain medical conditions. It's also higher if you're on bedrest after surgery. Your gynecologist might temporarily stop Prempro for 4-6 weeks before surgery. Talk with your gynecologist if you have any questions regarding your risk of blood clots.

                          risk-warning

                          Breast cancer

                          • Risk factors: Personal or family history of breast cancer | Using Prempro for more than one year

                            Taking hormone replacement therapy with estrogen and progestin, like Prempro, can raise your risk of breast cancer. The longer you take this medication, the higher your risk is. That's why it's best to take this medication only for the shortest time necessary. Talk to your prescriber about ways to lower your risk, especially if you or a family member has had breast cancer. Make sure to check your breasts regularly for changes and get breast scans (mammograms). Let your prescriber know if you notice any unusual changes in breast shape, size, or color.

                            risk-warning

                            Uterine (endometrial) cancer

                            • Risk factors: Estrogen therapy without additional progestin | Using estrogen therapy for more than 1 year

                              Vaginal bleeding after menopause can be a warning sign of uterine (endometrial) cancer, so let your prescriber know if you notice any unusual bleeding. Even though this Prempro contains a progestin to help protect your uterus, you should still report any unusual bleeding to your prescriber right away.

                              risk-warning

                              Dementia

                              • Risk factors: Age over 65

                                People taking medications containing estrogen, such as Prempro, might have a higher risk of dementia. Experts aren't sure why, but your risk is highest if you start taking Prempro for the first time after age 65. Early symptoms of dementia include new forgetfulness, confusion, getting lost, and wandering out. If you’re concerned about this risk, talk to your prescriber.

                                risk-warning

                                Gallbladder and liver problems

                                • Risk factors: History of or current liver problems

                                  Prempro can cause problems with your gallbladder, and some people have needed gallbladder surgery after starting this medication. If you experience stomach pain, nausea or vomiting that doesn't go away, fever, or a yellowing of the skin and eyes (jaundice), speak with your prescriber or get medical attention right away.

                                  The estrogen in Prempro is processed by the liver. So if your liver isn't working properly, you might have more side effects from this medication. If you currently have or have had any liver problems, including issues during a past pregnancy, you shouldn't use Prempro.

                                  risk-warning

                                  Changes in calcium levels in the blood

                                  • Risk factors: History of breast cancer | Cancer that has spread to the bones | Low parathyroid hormone levels

                                    Taking Prempro can lead to severely high calcium levels in people with breast cancer that has spread to their bones. High calcium can cause symptoms like thirst, stomach pain, nausea, vomiting, constipation, bone pain, muscle weakness, or confusion. Tell your prescriber if you have any of these symptoms because you might have to stop taking Prempro.

                                    Use Prempro carefully if you have low parathyroid hormone levels (hypoparathyroidism), which can lead to low calcium in your body. Let your prescriber know if you have signs of low calcium such as burning or tingling of your fingers, toes, or lips, muscle pain and cramps, or confusion.

                                    risk-warning

                                    Vision problems

                                    Although very rare, some people taking estrogens have experienced vision problems caused by a blood clot in the eyes. If you have sudden partial or complete vision loss, bulging eyes, double vision, or migraines, stop taking Prempro and tell your prescriber immediately.

                                    risk-warning

                                    High triglycerides

                                    • Risk factors: High levels of triglycerides

                                      Estrogens can raise the amount of fats in your blood (triglycerides), which can lead to heart problems or pancreatitis, a serious inflammation of the pancreas. Your prescriber might recommend regular blood tests to watch for this while you're taking Prempro. If you experience sudden stomach or back pain, nausea, vomiting, sudden weight loss, or a fast heart rate, contact your prescriber or seek medical care right away.

                                      risk-warning

                                      Low thyroid hormone levels (hypothyroidism)

                                      • Risk factors: Low thyroid hormone levels

                                        Prempro can affect thyroid hormone levels in your blood. If you're taking medications for low thyroid hormone levels, you might need a higher dose of your thyroid replacement therapy. Your prescriber might recommend regular blood tests to check your thyroid hormone levels while you're taking this medication.

                                        risk-warning

                                        Fluid Retention

                                        • Risk factors: History of heart or kidney problems

                                          Estrogen products like Prempro can cause some fluid retention or edema, especially in people with heart conditions, like congestive heart failure, or kidney problems. If you notice unusual swelling in any part of your body or if you suddenly gain weight over a short period of time, let your care team know.

                                          risk-warning

                                          Severe allergic reaction

                                          Serious allergic reactions like anaphylaxis have been reported in people taking Prempro. These reactions can happen within minutes to hours and can require emergency treatment. Let your prescriber know if you have symptoms including trouble breathing, hives, itching, or swelling of your lips, tongue, or face.

                                          risk-warning

                                          Worsening of other medical conditions

                                          • Risk factors: History of asthma or diabetes | History of lupus | History of seizures or migraines | Taking other medications that can cause seizures

                                            Taking estrogen-containing medications like Prempro can worsen certain medical conditions. These include high blood pressure, hereditary angioedema, asthma, diabetes, migraine, and seizures. Before you start Prempro let your healthcare team know about your past medical history so they can talk with you about the risks and benefits of taking this medication.

                                            dosage

                                            Prempro dosage forms

                                            The average cost for 1 package of 28 tablets of 0.3mg/1.5mg of Prempro is $98.84 with a free GoodRx coupon. This is 69.19% off the average retail price of $320.76.
                                            package
                                            Package
                                            DosageQuantityPrice as low asPrice per unit
                                            28 tablets of 0.3mg/1.5mg1 package$98.84$98.84
                                            28 tablets of 0.45mg/1.5mg1 package$98.84$98.84
                                            28 tablets of 0.625mg/2.5mg1 package$98.84$98.84
                                            28 tablets of 0.625mg/5mg1 package$98.84$98.84

                                            Typical dosing for Prempro

                                            • Prempro: Take 1 tablet by mouth once daily.

                                              • Since conjugated estrogens and medroxyprogesterone come in different strengths, ask your prescriber which strength is right for you.

                                            • Premphase: Take 1 dark-red tablet by mouth once daily on days 1 through 14. Then take 1 light-blue tablet by mouth once daily on days 15 through 28.

                                              • The dark-red tablet contains 0.625 mg of conjugated estrogens and the light-blue tablet contains 0.625 mg conjugated estrogens plus 5 mg of medroxyprogesterone.

                                            interactions

                                            Interactions between Prempro and other drugs

                                            Prempro may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Prempro. Please note that only the generic name of each medication is listed below.

                                            Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                            Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                            Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                            drug-cost

                                            How much does Prempro cost?

                                            To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                                            Prempro (brand)
                                            GoodRx lowest price

                                            $98.84

                                            (save 69.19%)
                                            View prices & coupons
                                            contraindications-icon

                                            Prempro contraindications

                                            Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Prempro will not be safe for you to take.

                                            • Undiagnosed abnormal bleeding from your genitals

                                            • History of breast cancer

                                            • History of cancer that depends on estrogen for growth

                                            • Blood clots or blood clotting conditions

                                            • History of stroke or heart attack

                                            • Liver problems

                                            • Currently pregnant

                                            alternatives

                                            What are alternatives to Prempro?

                                            There are a number of medications that your doctor can prescribe in place of Prempro. Compare a few possible alternatives below.
                                            Prempro
                                            Used for:
                                            $98.84 Lowest GoodRx priceView Prices
                                            Prefest (estradiol / norgestimate)
                                            Used for:

                                            • Hot flashes, night sweats, and flushes caused by menopause

                                            • Vaginal dryness and burning caused by menopause

                                            • Prevention of postmenopausal osteoporosis (not a first-choice)

                                            $583.48 Lowest GoodRx priceView Prices
                                            Angeliq (drospirenone / estradiol)
                                            Used for:
                                            $185.69 Lowest GoodRx priceView Prices
                                            images

                                            Prempro images

                                            beige oval - Prempro 0.3mg-1.5mg Tablet
                                            This medicine is Beige, Oval Package.beige oval - Prempro 0.3mg-1.5mg Tablet

                                            Get savings updates for Prempro

                                            Receive price alerts, news, and other messages from GoodRx about Prempro and other healthcare topics and relevant savings offers.

                                            By providing your email, you consent to receive marketing communications from GoodRx, which may include content and/or data related to men’s health, women's health, reproductive care, or sexual health. You agree to the GoodRx Terms of Use and acknowledge the Privacy Policy. You can unsubscribe at any time.

                                            References

                                            Best studies we found

                                            American College of Obstetricians and Gynecologists. (2024). Hormone therapy for menopause.

                                            Rehak, M., et al. (2010). Retinal vein thrombosis: Pathogenesis and management. Journal of Thrombosis and Haemostasis.

                                            Rosendaal, F. R., et al. (2002). Female hormones and thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology.

                                            View All References (1)

                                            Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc. (2024). Premphase- conjugated estrogens and medroxyprogesterone acetate kit; Prempro- conjugated estrogens and medroxyprogesterone acetate tablet, sugar coated [package insert]. DailyMed.

                                            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                                            Was this page helpful?

                                            Compare other Osteoporosis, Menopause drugs

                                            Estradiol vs PremproPremarin Vaginal Cream vs PremproPremarin vs PremproPrempro vs AloraPrempro vs ClimaraPrempro vs Depo EstradiolPrempro vs DivigelPrempro vs ElestrinPrempro vs Estrace Vaginal CreamPrempro vs Estradiol NorethindronePrempro vs Estradiol PatchPrempro vs EstringPrempro vs EvamistPrempro vs MinivellePrempro vs ProveraPrempro vs Vivelle DotEstrace Vaginal Cream vs DivigelEstradiol Norethindrone vs DivigelEstradiol Norethindrone vs EvamistEstradiol Norethindrone vs PrefestEstradiol Norethindrone vs ProveraEstradiol Patch vs Estradiol NorethindroneEstring vs Estrace Vaginal CreamEstring vs Estradiol NorethindroneMinivelle vs Estradiol NorethindronePremarin Vaginal Cream vs Estrace Vaginal CreamPremarin Vaginal Cream vs Estradiol NorethindronePremarin vs Estrace Vaginal CreamProvera vs Estrace Vaginal CreamVivelle Dot vs Estrace Vaginal Cream
                                            View More

                                            Browse medications

                                            View All

                                            Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.