Minocycline is an antibiotic that treats many types of bacterial infections, including urinary tract infections (UTIs) and sinus infections. It's also used to treat acne when medications that are applied onto the skin aren't working well. Some common side effects include headache, feeling tired, and dizziness. Minocycline can also stain children's teeth and make you more like to get a sunburn.
Moderate-to-severe acne
Respiratory tract infections, including in the nose, throat, and lungs
Sexually transmitted infections (STIs) like chlamydia, gonorrhea, chancroid, and syphilis
Skin infections
Rickettsial infections (usually from ticks, fleas, or mites), such as Rocky Mountain spotted fever and typhus fever
Other infections such as anthrax, plague, cholera, and more. Minocycline can be used to treat many other less common infections not listed here.
Minocycline is a tetracycline antibiotic. It prevents bacteria from making certain proteins, which stops them from multiplying and spreading in your body. For acne, minocycline lowers the amount of the P. acnes bacteria that live naturally on your skin. This can help lessen inflammation and acne.
Source: DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Incidence not known
Black, tarry stools
blistering, peeling, or loosening of the skin
blood in the urine or stools
blurred or double vision
bulging soft spot on the head of an infant
chest pain, possibly moving to the left arm, neck, or shoulder
confusion
dizziness or lightheadedness
fast heartbeat
general feeling of discomfort or illness
general tiredness and weakness
joint or muscle pain
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
loss of appetite
nausea or vomiting
red skin lesions, often with a purple center
severe headache
severe stomach pain
sores, ulcers, or white spots on the lips or in the mouth
troubled breathing
unusual bleeding or bruising
upper right abdominal or stomach pain
yellow eyes and skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Continuing ringing or buzzing or other unexplained noise in the ears
difficulty with moving
hearing loss
hives or welts
muscle stiffness
redness of the skin
sleepiness or unusual drowsiness
Incidence not known
discoloration of the tooth
increased sensitivity of the skin to sunlight
indigestion
severe sunburn
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Works well against certain types of acne
A good alternative for some infections if you're allergic to penicillin
Can take with or without food
Might have a lower risk of infectious diarrhea than other antibiotics
Available as a lower-cost generic
Can make you get sunburns easier
Can stain children's teeth during tooth development
Interacts with blood thinners and birth control pills
Not recommended if you're pregnant or breastfeeding
Not available as an oral liquid
You can take minocycline with or without food. Taking it with food can help prevent the medication from irritating your esophagus (the pipe that moves food and medications down into your stomach). Drinking plenty of fluids with your dose and staying in an upright position for a while after taking each dose can also help prevent this problem.
Minocycline capsules and tablets should be swallowed whole, with the exception of Minolira tablets. Minolira tablets can be broken on the scored line if needed.
Finish all of the minocycline your healthcare provider prescribed for you, even if you start to feel better. Stopping minocycline too soon can cause your infection to come back and be harder to treat.
When you first start minocycline treatment, you might feel dizzy or faint, which can affect your focus and sense of balance. This side effect typically gets better with time and then goes away after you've stopped treatment. Be careful driving or performing tasks that require concentration until you know how minocycline makes you feel.
Minocycline makes your skin more sensitive to the sun, which means you might get sunburns very easily. Make sure to avoid sun exposure and tanning beds. Protect your skin by wearing a wide-brimmed hat. Also use sunscreen with an SPF of at least 30 when you go outside, even on overcast days and during the winter.
Minocycline interacts with blood thinners, such as warfarin (Coumadin). Be sure to let the provider who prescribes your blood thinner know if you have to take this antibiotic so they can follow up with you more often.
Whether you're male or female, talk to your provider if you're thinking of having a child before taking minocycline since it could cause harm to babies.
Minocycline can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Minocycline can cause harm to unborn babies, such as abnormal bone development. Whether you're male or female, it's not recommended to take this medication if you're trying to have a child. Keep in mind that minocycline can cause some birth control pills to work less well, so it's recommended to use a second birth control method during treatment. If you become pregnant while taking minocycline, stop taking the medication and call your provider.
Risk factors: Females in the last half of their pregnancy | Children age 8 or younger | Using minocycline for a long time or multiple times
Tetracycline antibiotics like minocycline can affect the teeth when they're still growing in young children. Usually, the teeth will permanently turn a yellow, gray, or brown color. Though rare, the teeth might not grow to be as strong because the enamel is also affected. This side effect can also happen to an unborn baby if the mother takes minocycline during the second half of her pregnancy. More generally, side effects affecting the teeth are more common during long-term use of minocycline, but can also happen after short courses.
Risk factors: Use of multiple antibiotics | Long-term use of antibiotics | Older age | Recent hospital stay | People with weakened immune systems | Previous infection from or known exposure to Clostridioides difficile
Antibiotics, including minocycline, can cause infectious diarrhea known as Clostridium difficile-associated diarrhea (commonly known as C. diff). This sometimes happens because antibiotics get rid of the good bacteria in your gut, leading to growth of other bacteria like C. diff. C. diff diarrhea is very contagious and can lead to life-threatening dehydration. Tell your healthcare provider right away if you have loose or watery stools, fever, stomach pain and cramps, nausea, vomiting, or loss of appetite.
In some rare cases, people have developed serious, potentially life-threatening allergic or skin reactions after starting minocycline. Get medical help right away if you notice you have trouble breathing, swelling, a new rash, a rash with a fever, unexplained blisters, or new sores inside your mouth.
Risk factors: History of kidney or liver problems
Sometimes, minocycline can harm the kidneys, especially if you already have kidney problems. Although rare, minocycline can also cause liver damage that can sometimes lead to liver failure. Contact your provider right away if you notice a dark urine, a change in urination, stomach pain, or yellowing of your skin or whites of your eyes.
Risk factors: Females who are of childbearing age and are either overweight or have history of high pressure in the brain | Also taking isotretinoin
Some people who took tetracycline antibiotics like minocycline reported developing high pressure in the brain, or a condition called intracranial hypertension. The risk is higher if you're also taking another acne medication called isotretinoin since it's known to cause this problem. Signs and symptoms of high pressure in the brain usually go away after you stop taking minocycline, but it can cause permanent vision problems. Call your healthcare provider right away if you experience a headache and changes in your eyesight, including blurry vision, double vision, or vision loss.
Minocycline can make your skin and nails darker. This effect can happen even if you haven't been taking minocycline for very long. The same thing can happen to other parts of the body as well, including the eyes, inside the mouth, and even some internal organs. These color changes usually aren't harmful. But, if this happens, check in with your provider to make sure it isn't a sign of other health problems.
Risk factors: Using minocycline for a long period of time
It's possible to get a new infection from fungi or bacteria that can't be treated with minocycline after using the medication for a while. Don't use minocycline longer than prescribed. Let your provider know if you notice symptoms of a new infection or if the original symptoms don't get any better after using minocycline.
Using tetracycline antibiotics like minocycline might be linked to autoimmune problems, particularly in people using the medication for acne for a long time. These problems can include inflammation of the liver or blood vessels, fever, rash, joint pain, or general discomfort. If you notice these symptoms after taking minocycline for a while, stop the medication and check in with your provider.
Adults: Your dose will depend on the reason why you're taking minocycline. For most infections, the typical dose is 200 mg by mouth for one time, then 100 mg by mouth every 12 hours. Another dosing option is 100 mg or 200 mg by mouth for one time, then 50 mg by mouth 4 times a day.
Children over 8 years old: Your child's provider will calculate their dose based on their body weight. The typical dose is 4 mg/kg of weight (up to 200 mg per dose) by mouth for one time, then 2 mg/kg of weight(up to 100 mg per dose) by mouth every 12 hours.
Extended-release tablets (Solodyn, Minolira) or capsules (Ximino) for acne only (ages 12 years and older): Your dose will be based on your body weight. The typical dose is 1 mg/kg of weight by mouth once daily for 12 weeks.
Minocycline is also available as an intravenous (IV) injection that's given by a healthcare provider.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Moderate-to-severe acne
Respiratory tract infections, including in the nose, throat, and lungs
Sexually transmitted infections (STIs) like chlamydia, gonorrhea, chancroid, and syphilis
Skin infections
Rickettsial infections (usually from ticks, fleas, or mites), such as Rocky Mountain spotted fever and typhus fever
Other infections such as anthrax, plague, cholera, and more. Minocycline can be used to treat many other less common infections not listed here.
Respiratory tract infections, including in the nose, throat, and lungs
Infections caused by ticks, mites, or fleas (Rocky Mountain spotted fever or typhus fever)
Sexually-transmitted infections (STIs) like chlamydia, gonorrhea, chancroid, and syphilis
Lyme disease
Urinary tract infections (UTIs)
Severe acne
Anthrax
Plague
Cholera
Bone and joint infections
Gonorrhea in the genitals
Long-term prostate infections
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