Oxaprozin (Daypro) is a prescription nonsteroidal anti-inflammatory drug (NSAID) that can help relieve arthritis pain in adults and children age 6 years and older. It's taken by mouth once per day. As with other NSAIDs, it can have side effects like stomach pain and heartburn.
Oxaprozin (Daypro) is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking proteins in your body (called cyclooxygenase or COX) that cause inflammation, pain, and swelling.
| Common Brands | Daypro |
|---|---|
| Drug Class | NSAID |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Contact your healthcare provider immediately if you experience any of the following.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Skin rash
Less common
bloody or black, tarry stools
burning upper abdominal or stomach pain
burning while urinating
cloudy urine
decrease in urine output or decrease in urine-concentrating ability
difficult or painful urination
headache
indigestion
itching skin
loss of appetite
nausea or vomiting
pale skin
severe abdominal or stomach pain, cramping, or burning
severe and continuing nausea
swelling
troubled breathing with exertion
unusual bleeding or bruising
unusual tiredness or weakness
vomiting of blood or material that looks like coffee grounds
Rare
Agitation
bleeding gums
blistering, peeling, or loosening of the skin
blurred vision
body aches or pain
burning feeling in chest or stomach
changes in blood pressure
clay-colored stools
coma
confusion
cough or hoarseness
cracks in the skin
dark urine
difficult or labored breathing
difficulty swallowing
dilated neck veins
dizziness
ear congestion
extreme fatigue
fainting
feeling of discomfort
fever or chills
fluid-filled skin blisters
high fever
hives or welts
hostility
increased sensitivity of the skin to sunlight
increased thirst
increased volume of pale, dilute urine
inflammation of the joints
irregular, fast or slow, or shallow breathing
joint or muscle pain
large, flat, blue or purplish patches in the skin
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
lethargy
light-colored stools
lightheadedness
loss of heat from the body
loss of voice
lower back or side pain
muscle aches
muscle twitching
noisy breathing
pain or burning in the throat
pain or tenderness around the eyes and cheekbones
pale or blue lips, fingernails, or skin
pinpoint red or purple spots on the skin
pounding in the ears
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
rapid weight gain
red skin lesions, often with a purple center
red, irritated eyes
redness or other discoloration of the skin
redness, swelling, or soreness of tongue
seizures
severe sunburn
skin thinness
slow, fast, irregular, pounding, or racing heartbeat or pulse
sores, ulcers, or white spots on the lips or tongue or inside the mouth
stuffy or runny nose
stupor
swelling of the face, fingers, feet, or lower legs
swelling or inflammation of the mouth
swollen lymph glands
tenderness in the stomach area
tightness in the chest
unpleasant breath odor
upper right abdominal or stomach pain
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Acid or sour stomach
belching
stomach discomfort
Less common
Continuing ringing or buzzing or other unexplained noise in the ears
excess air or gas in the stomach or intestines
hearing loss
passing gas
relaxed and calm
sleepiness or unusual drowsiness
trouble sleeping
Rare
Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
burning, dry, or itching eyes
change in taste
decreased hearing
discharge, excessive tearing
feeling of constant movement of self or surroundings
general feeling of discomfort or illness
lack or loss of strength
redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
sensation of spinning
shakiness in the legs, arms, hands, feet
trembling or shaking of the hands or feet
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Oxaprozin (Daypro) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Oxaprozin (Daypro), like all NSAIDs, raises your risk for stomach ulcers (sores) and bleeds. Stomach bleeding is a dangerous condition that requires treatment right away. Make sure to tell your provider or pharmacist about all of your medical conditions and medications before starting oxaprozin (Daypro) so they can talk with you about your risk for stomach bleeding. If you're feeling faint, vomiting blood, have bloody or dark stools, or have severe stomach pain or discomfort that doesn't go away while taking oxaprozin (Daypro), get medical attention right away.
Oxaprozin (Daypro) can raise your risk of having blood clots, which can cause a heart attack or stroke. Your provider will prescribe the lowest dose of oxaprozin (Daypro) for the shortest period of time possible. If you have heart problems, talk to your healthcare provider before starting this medication. Don't take oxaprozin (Daypro) if you had, or will have, heart surgery. Call 911 or get medical help right away if you experience chest pain, shortness of breath, weakness on one side of your body, or trouble speaking or walking.
Oxaprozin (Daypro) can cause your body to hold onto extra fluid, which can raise your blood pressure or put you at risk for heart failure. Tell your provider if you have a history of heart problems or are taking blood pressure medications before starting oxaprozin (Daypro) to make sure it's safe for you. Your provider will check for heart problems before they prescribe this medication to you. If you experience unexplained fainting, chest pain with physical activity, or irregular heartbeat while taking oxaprozin (Daypro), contact your provider.
Oxaprozin (Daypro) can cause kidney problems. Your risk is higher if you have certain factors like older age, certain medical problems like diabetes, or you're taking medications that can cause kidney problems. Your provider might order blood tests to monitor your kidney health before and during treatment with oxaprozin (Daypro). If your kidney health worsens, your provider might stop your oxaprozin (Daypro) treatment. Contact your provider if you develop any signs or symptoms of kidney failure, including changes in your need to urinate, tiredness, dry and itchy skin, low appetite, and muscle cramps.
Although rare, oxaprozin (Daypro) can cause serious liver problems that can lead to liver failure. Get medical attention right away if you notice swelling of your stomach, stomach pain, yellowing of your skin or the whites of your eyes, stool changes (black, tarry, or bloody stools), nausea, vomiting, confusion, or dark or brown urine. You might need to stop using the medication to prevent further liver damage.
Severe allergic reactions to oxaprozin (Daypro) are possible, including life-threatening reactions like facial swelling, shock, and anaphylaxis. Let your provider know if you have an allergy to aspirin or other NSAIDs before starting oxaprozin (Daypro). If you notice hives, rash, red skin, swelling of the lips or tongue, or difficulty breathing after using oxaprozin (Daypro), call for medical help as soon as possible.
Although rare, oxaprozin (Daypro) can cause serious skin reactions called Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug reaction with eosinophilia and systemic symptoms (DRESS). If you notice changes in your skin, such as rash, blisters, skin reddening, or skin peeling, stop using oxaprozin (Daypro) and get medical attention right away.
If you're pregnant or breastfeeding, talk to your provider first about the risk and benefits of oxaprozin (Daypro) before using this medication. Oxaprozin (Daypro) can cause harm to your unborn baby or complications during delivery if taken during the second half of pregnancy.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Oxaprozin (Daypro) will not be safe for you to take.
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If you need additional pain relief while taking Oxaprozin, it's generally safe to take over-the-counter acetaminophen (Tylenol) as long as you don't have liver problems. Make sure to ask your provider about how much acetaminophen (Tylenol) you can take. But, don't take other over-the-counter NSAIDs, like ibuprofen (Advil, Motrin) or naproxen (Aleve), because they belong to the same medication class as Oxaprozin. Taking more than one NSAID can raise your risk for severe side effects, such as heart problems, kidney problems, or bleeds. Make sure to check the manufacturer label carefully to see if a specific product contains an NSAID. Ask your provider or pharmacist if you're not sure if you can take a particular over-the-counter pain medication with Oxaprozin.
Oxaprozin isn't typically used as needed for arthritis pain. It's usually taken every day on a regular basis. If you feel that you don't need to take Oxaprozin every day, talk to your provider. They can discuss options that best fit your needs, such as the possibility of taking Oxaprozin as needed or switching to a different pain medication.
It's recommended that you limit the amount of alcohol you drink if you're taking Oxaprozin. This is because drinking alcohol while taking Oxaprozin can raise your risk for stomach bleeds. But if you have other conditions that put you at higher risk for bleeds (e.g., older age, taking a blood thinner), your provider might advise you to avoid alcohol completely. Speak with your provider about your alcohol consumption and whether it's safe for you to drink alcohol during treatment with Oxaprozin.
It's not clear whether or not Oxaprozin is safe to take during early pregnancy. But the FDA recommends that you avoid taking Oxaprozin during the second half of pregnancy (week 20 of pregnancy or later) because it might cause harm to your unborn baby or complications during delivery. If you're pregnant, speak with your provider about safer medications you can take for arthritis pain.
There haven't been any studies done to know for sure whether or not Oxaprozin is safe to take while breastfeeding. It's recommended to use a different medication to relieve arthritis pain while breastfeeding. Discuss with your provider about the risks and benefits of using Oxaprozin while breastfeeding to make sure this medication is safe for you and your baby.
