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Oxaprozin

Oxaprozin Side Effects

Robert Chad Hakim, PharmD, BCCCPAllison Gourley, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Allison Gourley, PharmD
Last reviewed on March 27, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Stomach pain or discomfort
  • Upset stomach or indigestion
  • Constipation
  • Diarrhea
  • Nausea
  • Rash

Less Common Side Effects

  • Loss of appetite
  • Vomiting
  • Gas
  • Dizziness
  • Headache
  • Ringing in ears
  • Anemia

Oxaprozin serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Stomach bleeding: feeling faint, vomiting blood, bloody or dark stools, severe stomach pain or discomfort
  • Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw
  • Stroke: chest pain, trouble breathing, weakness in one part of your body or face, slurred speech
  • Heart failure: difficulty breathing, swelling, fast heartbeat
  • Liver problems: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine
  • Kidney problems: tiredness, dry and itchy skin, low appetite, urinating less than usual, foamy or bloody urine, muscle cramps
  • Allergic reactions: hives, rash, blisters, swelling of the lips or tongue, difficulty breathing
  • Serious skin reactions: skin reddening, blisters, rash

Source: DailyMed

The following Oxaprozin side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Skin rash

Less common

Bloating

bloody or black, tarry stools

burning upper abdominal or stomach pain

burning while urinating

cloudy urine

constipation

decrease in urine output or decrease in urine-concentrating ability

diarrhea

difficult or painful urination

frequent urination

headache

heartburn

indigestion

itching skin

loss of appetite

nausea or vomiting

pale skin

severe abdominal or stomach pain, cramping, or burning

severe and continuing nausea

swelling

troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

vomiting of blood or material that looks like coffee grounds

weight loss

Rare

Agitation

bleeding gums

blistering, peeling, or loosening of the skin

blurred vision

body aches or pain

burning feeling in chest or stomach

changes in blood pressure

chest pain

clay-colored stools

coma

confusion

cough or hoarseness

cracks in the skin

dark urine

depression

difficult or labored breathing

difficulty swallowing

dilated neck veins

dizziness

ear congestion

extreme fatigue

fainting

feeling of discomfort

fever or chills

fluid-filled skin blisters

high fever

hives or welts

hostility

increased sensitivity of the skin to sunlight

increased thirst

increased volume of pale, dilute urine

inflammation of the joints

irregular, fast or slow, or shallow breathing

joint or muscle pain

large, flat, blue or purplish patches in the skin

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

lethargy

light-colored stools

lightheadedness

loss of heat from the body

loss of voice

lower back or side pain

muscle aches

muscle twitching

noisy breathing

pain or burning in the throat

pain or tenderness around the eyes and cheekbones

pale or blue lips, fingernails, or skin

pinpoint red or purple spots on the skin

pounding in the ears

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid weight gain

red skin lesions, often with a purple center

red, irritated eyes

redness or other discoloration of the skin

redness, swelling, or soreness of tongue

scaly skin

seizures

severe sunburn

skin thinness

slow, fast, irregular, pounding, or racing heartbeat or pulse

sneezing

sore throat

sores, ulcers, or white spots on the lips or tongue or inside the mouth

stuffy or runny nose

stupor

swelling of the face, fingers, feet, or lower legs

swelling or inflammation of the mouth

swollen lymph glands

tenderness in the stomach area

tightness in the chest

unpleasant breath odor

upper right abdominal or stomach pain

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach

belching

stomach discomfort

Less common

Continuing ringing or buzzing or other unexplained noise in the ears

excess air or gas in the stomach or intestines

hearing loss

passing gas

relaxed and calm

sleepiness or unusual drowsiness

trouble sleeping

Rare

Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

burning, dry, or itching eyes

change in taste

decreased hearing

discharge, excessive tearing

dry mouth

feeling of constant movement of self or surroundings

general feeling of discomfort or illness

lack or loss of strength

redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid

sensation of spinning

shakiness in the legs, arms, hands, feet

trembling or shaking of the hands or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.

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